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PHR1602

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Losartan-Kalium

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

2-Butyl-4-chlor-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-Imidazol-5-methanol-Kaliumsalz, 2-Butyl-4-chlor-1-{[2′-(1H-tetrazol-5-yl)-(1,1′-biphenyl)-4-yl]-methyl}-1H-imidazol-5-methanol Monokaliumsalz, DuP 753, Kalium-5-(4′-((2-butyl-4-chlor-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)tetrazol-1-id, MK 954

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About This Item

Empirische Formel (Hill-System):
C22H22ClKN6O
CAS-Nummer:
124750-99-8
Molekulargewicht:
461.00
Beilstein:
5845770
MDL-Nummer:
MFCD02092704
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329823502
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

300

Agentur

traceable to BP 867
traceable to Ph. Eur. Y0001062
traceable to USP 1370462

API-Familie

losartan

Analysenzertifikat (CofA)

current certificate can be downloaded

Verpackung

pkg of 1 g

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-30°C

SMILES String

CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]

InChI

1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1

InChIKey

OXCMYAYHXIHQOA-UHFFFAOYSA-N

Angaben zum Gen

human ... AGTR1(185)

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Verwandte Kategorien

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Losartan Potassium is a novel class of orally active, non-peptide angiotensin II (type AT1) receptor antagonist drug that can be used in the remedy of hypertension. It exhibits superior activity than many other peptide receptor antagonist drugs and angiotensin converting enzyme (ACE) inhibitors owing to the high specificity, selectivity, and tolerability.

Anwendung

Losartan Potassium may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques and spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Losartankalium ist ein oral verabreichter, wirksamer und selektiver kompetitiver Angiotensin-II-Rezeptortyp-1(AT1)-Antagonist. Losartankalium wird zur Behandlung von Hypertonie eingesetzt.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAC0141 in the slot below. This is an example certificate only and may not be the lot that you receive.

Empfohlene Produkte

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Ähnliches Produkt

Produkt-Nr.
Beschreibung
Preisangaben

Y0001076

Losartan für die Systemeignung, European Pharmacopoeia (EP) Reference Standard

Y0001072

Losartan Unreinheit D, European Pharmacopoeia (EP) Reference Standard

Y0001062

Losartan-Kalium, European Pharmacopoeia (EP) Reference Standard

1695343

Triphenylmethanol, United States Pharmacopeia (USP) Reference Standard

1370473

Losartan-verwandte Verbindung A, United States Pharmacopeia (USP) Reference Standard

1370495

Losartan-verwandte Verbindung C, United States Pharmacopeia (USP) Reference Standard

1370484

Losartan-verwandte Verbindung B, United States Pharmacopeia (USP) Reference Standard

1370509

Losartan-verwandte Verbindung D, United States Pharmacopeia (USP) Reference Standard

1370510

Losartan-verwandte Verbindung E, United States Pharmacopeia (USP) Reference Standard

BP867

Losartan-Kalium, British Pharmacopoeia (BP) Reference Standard

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number
LRAD5205
LRAC5655
LRAC0141
LRAA4718
LRAB1233

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

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Validated RP-HPLC method for simultaneous quantitation of losartan potassium and metolazone in bulk drug and formulation.
Dubey R, et al.
Scientia Pharmaceutica, 79(3), 545-554 (2011)
Development and validation of a stability-indicating HPLC method for the simultaneous determination of Losartan potassium, hydrochlorothiazide, and their degradation products.
Hertzog DL, et al.
Journal of Pharmaceutical and Biomedical Analysis, 30(3), 747-760 (2002)
Spectrophotometric and HPLC methods for simultaneous estimation of amlodipine besilate, losartan potassium and hydrochlorothiazide in tablets.
Wankhede SB, et al.
Indian Journal of Pharmaceutical Sciences, 72(1), 136-136 (2010)
H Salmenkari et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 69(4) (2018-11-12)
The renin-angiotensin system (RAS) in the intestine is involved in the regulation of inflammation, apoptosis and tissue fibrosis in experimental models of colitis; the inhibition of local RAS by pharmacologic interventions has been claimed to prevent and alleviate colitis. In

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