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PHR1443

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Irbesartan

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

2-Butyl-3-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]-methyl]-1,3-diazaspiro[4.4]non-1-en-4-on

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About This Item

Empirische Formel (Hill-System):
C25H28N6O
CAS-Nummer:
138402-11-6
Molekulargewicht:
428.53
MDL-Nummer:
MFCD00864464
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329822604
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

300

Agentur

traceable to BP 1093
traceable to Ph. Eur. Y0001166
traceable to USP 1347700

API-Familie

irbesartan

Analysenzertifikat (CofA)

current certificate can be downloaded

Verpackung

pkg of 1 g

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

CCCCC1=NC2(CCCC2)C(=O)N1Cc3ccc(cc3)-c4ccccc4-c5nnn[nH]5

InChI

1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)

InChIKey

YOSHYTLCDANDAN-UHFFFAOYSA-N

Angaben zum Gen

human ... AGTR1(185)

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Verwandte Kategorien

Allgemeine Beschreibung

Irbesartan is a potent, long-acting “sartan” class, nonpeptide, angiotensin II receptor antagonist utilized for the management of hypertension as well as heart failure in clinical patients. It shows high selectivity for the AT1 subtype (angiotensin I), and effectively reduces the probabilities of cardiac failure, myocardial infarction, sudden death, etc.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Anwendung

Irbesartan may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and combined dosage forms by chromatography and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAC2897 in the slot below. This is an example certificate only and may not be the lot that you receive.

Ähnliches Produkt

Produkt-Nr.
Beschreibung
Preisangaben

Y0001166

Irbesartan, European Pharmacopoeia (EP) Reference Standard

Y0001156

Irbesartan Unreinheit A, European Pharmacopoeia (EP) Reference Standard

1347711

Irbesartan-verwandte Verbindung A, United States Pharmacopeia (USP) Reference Standard

1347700

Irbesartan, United States Pharmacopeia (USP) Reference Standard

PHR1958

Irbesartan-verwandte Verbindung A, Pharmaceutical Secondary Standard; Certified Reference Material

BP1093

Irbesartan, British Pharmacopoeia (BP) Reference Standard

BP1122

Irbesartan-Unreinheit A, British Pharmacopoeia (BP) Reference Standard

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number
LRAD3685
LRAC2897
LRAB3210
LRAA2751

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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A novel dilute and shoot HPLC assay method for quantification of irbesartan and hydrochlorothiazide in combination tablets and urine using second generation C18-bonded monolithic silica column with double gradient elution
Koyuturk S, et al.
Journal of Pharmaceutical and Biomedical Analysis, 97(2), 103-110 (2014)
Electrochemical determination of antihypertensive drug irbesartan in pharmaceuticals
Gupta VK, et al.
Analytical biochemistry, 410(2), 266-271 (2011)
H-Point Standard Addition Method for Simultaneous Spectrophotometric Determination of Irbesartan, hydrochlorothiazide and Telmisartan in tablets
Sivasubramanian L and Lakshmi KS
International Journal of Research in Pharmacy and Chemistry, 4(2), 373-380 (2014)
Simultaneous determination of olmesartan medoxomil and irbesartan and hydrochlorothiazide in pharmaceutical formulations and human serum using high performance liquid chromatography
Sultana N, et al.
Se Pu / Chinese Journal of Chromatography, 26(5), 544-549 (2008)
Determination of hydrochlorothiazide and irbesartan in pharmaceuticals by fourth-order UV derivative spectrophotometry
Vetuschi C, et al.
Il Farmaco (Societa Chimica Italiana : 1989), 60(8), 665-670 (2005)
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