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PHR1307

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Captopril

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

N-[(S)-3-Mercapto-2-methylpropionyl]-L-prolin

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About This Item

Empirische Formel (Hill-System):
C9H15NO3S
CAS-Nummer:
62571-86-2
Molekulargewicht:
217.29
Beilstein:
477887
EG-Nummer:
263-607-1
MDL-Nummer:
MFCD00168073
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329823294
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

300

Agentur

traceable to BP 538
traceable to Ph. Eur. C0430000
traceable to USP 1091200

API-Familie

captopril

Analysenzertifikat (CofA)

current certificate can be downloaded

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

mp (Schmelzpunkt)

104-108 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-30°C

SMILES String

C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O

InChI

1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

InChIKey

FAKRSMQSSFJEIM-RQJHMYQMSA-N

Angaben zum Gen

human ... ACE(1636)

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Verwandte Kategorien

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Captopril acts by inhibiting the angiotensin-converting enzyme and is known as an antihypertensive agent. It finds wide use in the treatment of congestive heart failure.

Anwendung

Captopril may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various analytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Angiotensin Converting Enzyme-Hemmer. Hemmt die Bildung von Angiotensin II, einem bioaktiven Peptid, das die Angionese stimuliert und die Mikrogefäßdichte erhöht.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAA0067 in the slot below. This is an example certificate only and may not be the lot that you receive.

Ähnliches Produkt

Produkt-Nr.
Beschreibung
Preisangaben

1091200

Captopril, United States Pharmacopeia (USP) Reference Standard

1091221

Captoprildisulfid, United States Pharmacopeia (USP) Reference Standard

C0430000

Captopril, European Pharmacopoeia (EP) Reference Standard

Y0000435

Captopril Unreinheit E, European Pharmacopoeia (EP) Reference Standard

Y0001182

Captopril für die Systemeignung, European Pharmacopoeia (EP) Reference Standard

Y0001221

Captopril Unreinheit D, European Pharmacopoeia (EP) Reference Standard

Y0001219

Captopril Unreinheit B, European Pharmacopoeia (EP) Reference Standard

Y0001220

Captopril Unreinheit C, European Pharmacopoeia (EP) Reference Standard

Y0001450

Captopril Unreinheit J, European Pharmacopoeia (EP) Reference Standard

BP538

Captopril, British Pharmacopoeia (BP) Reference Standard

BP500

Captoprildisulfid, British Pharmacopoeia (BP) Reference Standard

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H341 - H360F

Gefahreneinstufungen

Muta. 2 - Repr. 1B

Lagerklassenschlüssel

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number
LRAC5115
LRAD5198
LRAA0067
LRAA9103

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

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Daidzein

Potentiometric determination of captopril in pharmaceutical formulations
Ribeiro PRDS, et al.
Ecletica Quimica, 28(1), 39-44 (2003)
Square-wave voltammetric (SWV) determination of Captopril in reconstituted serum and pharmaceutical formulations
Parham H and Zargar B
Talanta, 65(3), 776-780 (2005)
Validation of simultaneous volumetric and spectrophotometric methods for the determination of captopril in pharmaceutical formulations
Rahman N, et al.
Il Farmaco (Societa Chimica Italiana : 1989), 60(6-7), 569-574 (2005)
Determination of captopril and its degradation products by capillary electrophoresis
Hillaert S and Van den Bossche W
Journal of Pharmaceutical and Biomedical Analysis, 21(1), 65-73 (1999)
Analysis of captopril and hydrochlorothiazide combination tablet formulations by liquid chromatography
Kirschbaum J and Perlman S
Journal of Pharmaceutical Sciences, 73(5), 686-687 (1984)
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