SCC463
sBT-RMS Spontaneous Brain-tropic RET Melanoma-sorted Mouse Cell Line
Synonym(s):
Q61R NRAS melanoma cell line, SK-MEL-147, human melanoma cell line, human melanoma cells, metastatic melanoma cell line
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About This Item
UNSPSC Code:
41106514
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biological source
mouse
Quality Level
packaging
vial of ≥1X10⁶ vial
manufacturer/tradename
Millipore
technique(s)
cell culture | mammalian: suitable
shipped in
liquid nitrogen
storage temp.
−196°C
General description
SCC463 is a derivative of the SCC462 cell line. Parental SCC462 were isolated from a spontaneously occurring skin tumor in RET transgenic mice. The sBT-RMS cell line was isolated from the brain metastasis following the subdermal injection of RMS cells.5 sBT-RMS cells are more aggressive in brain metastasis than the parental RMS line and exhibited higher organ-specificity.
Application
- Each vial contains >1X106 viable cells.
- sBT-RMS cells are verified to be of mouse origin and negative for human, rat, Chinese hamster, Golden Syrian hamster, and non-human primate interspecies contamination, as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
- Cells tested negative for infectious diseases against a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
- Cells tested negative for mycoplasma.
Features and Benefits
SCC463, the sBT-RMS spontaneous brain-tropic RET melanoma-sorted mouse cell line, demonstrates more aggressive brain metastasis than the parental RMS cell line, and exhibits higher organ specificity.
Target description
The RET oncogene was originally created by an accidental in vivo recombination of two human genes, RET and RFP (the RET-finger protein, known today as TRIM27), during a transformation of NIH3T3 cells with human lymphoma DNA (Takahashi 1985). The founder R
Storage and Stability
sBT-RMS cells should be stored in liquid nitrogen until use. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Other Notes
This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact l
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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