Skip to Content
Merck
All Photos(1)

Documents

PHR1191

Supelco

Nitrofurantoin

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

N-(5-Nitro-2-furfurylidene)-1-aminohydantoin, Furadoxyl, Nitrofurantoine

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C8H6N4O5
CAS Number:
67-20-9
Molecular Weight:
238.16
Beilstein:
893207
EC Number:
200-646-5
MDL number:
MFCD00003224
UNSPSC Code:
41116107
PubChem Substance ID:
329823199
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1464001

API family

nitrofurantoin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

[O-][N+](=O)c1ccc(\C=N\N2CC(=O)NC2=O)o1

InChI

1S/C8H6N4O5/c13-6-4-11(8(14)10-6)9-3-5-1-2-7(17-5)12(15)16/h1-3H,4H2,(H,10,13,14)/b9-3+

InChI key

NXFQHRVNIOXGAQ-YCRREMRBSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Nitrofurantoin, a synthetic, nitrofuran-derivative, is a widely used urinary antimicrobial compound that is effective against pulmonary fibrosis, neuropathy, hepatitis and hemolytic anemia.

Application

Nitrofurantoin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by voltammetry and chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA9007 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Exclamation markHealth hazard
GHS07,GHS08

Signal Word

Danger

Hazard Statements

H302 - H317 - H334

Hazard Classifications

Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC4516
LRAC6352
P500191
LRAA9007

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 5

1 of 5

Cimaterol VETRANAL®, analytical standard

Supelco

32568

Cimaterol

Trimethoprim Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1056

Trimethoprim

Ciprofloxacin HCl Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1044

Ciprofloxacin HCl

Atovaquone Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1591

Atovaquone

Furosemide Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1057

Furosemide

Stripping voltammetric behaviour of toxic drug nitrofurantoin
Jain R, et al.
Journal of Hazardous Materials, 169(1-3), 667-672 (2009)
Liquid chromatographic and spectrophotometric determination of phenazopyridine hydrochloride, ampicilline trihydrate, and nitrofurantoine in pharmaceutical preparations
Palabiyik IM and Onur F
Analytical Letters, 37(10), 2125-2150 (2004)
Determination of nitrofurantoin drug in pharmaceutical formulation and biological fluids by square-wave cathodic adsorptive stripping voltammetry
Hammam E
Journal of Pharmaceutical and Biomedical Analysis, 30(3), 651-659 (2002)
Detection of ampicillin contamination in nitrofurantoin preparations by high pressure liquid chromatography
Bracey A
Journal of Pharmaceutical Sciences, 62(10), 1695-1696 (1973)
Brenda M Kazemier et al.
BMC pregnancy and childbirth, 12, 52-52 (2012-08-16)
The prevalence of asymptomatic bacteriuria (ASB) in pregnancy is 2-10% and is associated with both maternal and neonatal adverse outcomes as pyelonephritis and preterm delivery. Antibiotic treatment is reported to decrease these adverse outcomes although the existing evidence is of
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service