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1368008

USP

Liothyronin

United States Pharmacopeia (USP) Reference Standard

Synonym(e):

3,3′,5-Triiod-L-thyronin, O-(4-Hydroxy-3-iodphenyl)-3,5-diiod-L-tyrosin, Liothyronin, T3

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About This Item

Empirische Formel (Hill-System):
C15H12I3NO4
CAS-Nummer:
6893-02-3
Molekulargewicht:
650.97
Beilstein:
2710227
MDL-Nummer:
MFCD00002593
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329750059
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

liothyronine

Hersteller/Markenname

USP

mp (Schmelzpunkt)

234-238 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1

InChIKey

AUYYCJSJGJYCDS-LBPRGKRZSA-N

Angaben zum Gen

human ... THRA(7067) , THRB(7068)

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Liothyronine USP reference standard for use in specified quality tests and assays.

Also used to prepare standard, standard stock, Liothyronine stock, and resolution solutions for assay, and identification test according to given below monographs of the United States Pharmacopeia (USP):
  • Thyroid
  • Levothyroxine Sodium Tablets
  • Liothyronine Sodium Tablets

Hinweis zur Analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Sonstige Hinweise

Sales restrictions may apply.

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Beschreibung
Preisangaben

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H372

Gefahreneinstufungen

STOT RE 1

Lagerklassenschlüssel

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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L-Thyronine

Sigma-Aldrich

T5905

L-Thyronine

3,3′,5-Triiodothyroessigsäure ≥90%

Sigma-Aldrich

T7650

3,3′,5-Triiodothyroessigsäure

3,3′,5,5′-Tetraiodthyroessigsäure

Sigma-Aldrich

T3787

3,3′,5,5′-Tetraiodthyroessigsäure

3,5-Diiod-L-tyrosin Dihydrat crystalline

Sigma-Aldrich

D0754

3,5-Diiod-L-tyrosin Dihydrat

3,5-Diiod-L-Thyronin thyroid hormone analog

Sigma-Aldrich

D0629

3,5-Diiod-L-Thyronin

3,3′,5-Triiod-L-thyronin Natriumsalz powder, BioReagent, suitable for cell culture

Sigma-Aldrich

T6397

3,3′,5-Triiod-L-thyronin Natriumsalz

L-Thyroxin powder, BioReagent, suitable for cell culture

Sigma-Aldrich

T1775

L-Thyroxin

3,3′,5-Triiod-L-thyronin Natriumsalz γ-irradiated, powder, suitable for, suitable for cell culture

Sigma-Aldrich

T5516

3,3′,5-Triiod-L-thyronin Natriumsalz

Liothyronine Sodium Tablets
United States Pharmacopeia, 34(4), 2640-2640 (2013)
Sara Santos Bernardes et al.
Cell and tissue research, 357(3), 803-814 (2014-05-21)
The role of reactive oxygen species (ROS) in muscle protein hydrolysis and protein oxidation in thyrotoxicosis has not been explored. This study indicates that ROS play a role in skeletal muscle wasting pathways in thyrotoxicosis. Two experimental groups (rats) were
Akihiro Mouri et al.
Psychoneuroendocrinology, 48, 147-161 (2014-07-13)
Attention deficit/hyperactivity disorder (ADHD) has been reported in association with resistance to thyroid hormone, a disease caused by a mutation in the thyroid hormone receptor β (TRβ) gene. TRβ is a key protein mediating down-regulation of thyrotropin (TSH) expression by
Héctor F Escobar-Morreale et al.
The Journal of clinical endocrinology and metabolism, 90(8), 4946-4954 (2005-06-02)
Combined infusion of levothyroxine plus liothyronine, as opposed to levothyroxine alone, is the only way of restoring the concentrations of circulating TSH, T4, and T3 as well as those of both T4 and T3 in all tissues of thyroidectomized rats.
Erica Sarchielli et al.
Experimental neurology, 257, 130-147 (2014-05-06)
Grafting fetal striatal cells into the brain of Huntington's disease (HD) patients has raised certain expectations in the past decade as an effective cell-based-therapy for this devastating condition. We argue that the first requirement for successful transplantation is defining the
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