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PHR1613

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Levothyroxin

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

L-Thyroxin, 3,3′,5,5′′-Tetraiod-L-thyronin, 3-[4-(4-Hydroxy-3,5-diiodphenoxy)-3,5-diiodphenyl]-L-alanin, T4

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About This Item

Lineare Formel:
HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
CAS-Nummer:
51-48-9
Molekulargewicht:
776.87
Beilstein:
2228515
EG-Nummer:
200-101-1
MDL-Nummer:
MFCD00002595
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329823509
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

300

Agentur

traceable to Ph. Eur. L0570000
traceable to USP 1365000

API-Familie

levothyroxine

Analysenzertifikat (CofA)

current certificate can be downloaded

Verpackung

pkg of 1 g

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

mp (Schmelzpunkt)

223 °C (dec.) (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-30°C

SMILES String

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

InChIKey

XUIIKFGFIJCVMT-LBPRGKRZSA-N

Angaben zum Gen

human ... THRA(7067) , THRB(7068)

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Allgemeine Beschreibung

Levothyroxine is a thyroid hormone that is responsible for the physiological actions such as growth, cardiac functionality, and regulation of carbohydrates, lipid, and protein metabolisms.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Anwendung

Levothyroxine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations and bulk dosage forms and oral liquid formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAC1514 in the slot below. This is an example certificate only and may not be the lot that you receive.

Empfohlene Produkte

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H372

Gefahreneinstufungen

STOT RE 1

Lagerklassenschlüssel

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number
LRAD2318
LRAC1514
LRAB9086
LRAA4872

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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L-Thyroxin (T4) -Lösung 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

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L-Thyroxin (T4) -Lösung

Liothyronin-Natrium European Pharmacopoeia (EP) Reference Standard

L0700000

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L-Thyroxin Natriumsalz Pentahydrat γ-irradiated, powder, BioXtra, suitable for cell culture

Sigma-Aldrich

T0397

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Clomiphen -citrat (Salz)

3,5-Diiod-L-Thyronin thyroid hormone analog

Sigma-Aldrich

D0629

3,5-Diiod-L-Thyronin

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Determination of liothyronine and levothyroxine in thyroid preparations by liquid chromatography
Richheimer SL and Jensen CB
Journal of Pharmaceutical Sciences, 75(2), 215-217 (1986)
Oral liquid formulation of levothyroxine is stable in breakfast beverages and may improve thyroid patient compliance
Bernareggi A, et al.
Pharmaceutics, 5(4), 621-633 (2013)
The separation and determination of liothyronine and levothyroxine in tablets by reversed-phase high performance liquid chromatography
Smith DJ, et al.
Journal of Chromatographic Science, 19(2), 72-78 (1981)

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