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SML0038

Sigma-Aldrich

Fluvastatin sodium hydrate

≥98% (HPLC)

Synonym(e):

(±)-(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate

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About This Item

Empirische Formel (Hill-System):
C24H25FNO4 · Na · xH2O
CAS-Nummer:
93957-55-2
Molekulargewicht:
433.45 (anhydrous basis)
MDL-Nummer:
MFCD20488050
UNSPSC-Code:
12352204
PubChem Substanz-ID:
329825108
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

white to tan

Löslichkeit

H2O: ≥9 mg/mL

Ersteller

Novartis

Lagertemp.

2-8°C

SMILES String

O.[Na+].CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13

InChI

1S/C24H26FNO4.Na.H2O/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);;1H2/q;+1;/p-1/b12-11+;;/t18-,19-;;/m1../s1

InChIKey

KKEMYLLTGGQWCE-PMRANXHDSA-M

Anwendung

Fluvastatin sodium hydrate has been used:
  • to examine its effect on β -glucan-induced training on immunity
  • to investigate the effect of statins on the number of uncoupling protein 1 (UCP1)+ cells
  • to determine its effect on insulin degrading enzyme (IDE) secretion from astrocytes
  • to treat and study its effect on human umbilical vein endothelial cells (HUVECs) in vitro

Fluvastatin sodium hydrate has been used:
  • to test its anti-hepatitis C virus (HCV) activity
  • as a cholesterol inhibitor
  • to study its effects on β-glucan-induced monocyte immune training

Biochem./physiol. Wirkung

Fluvastatin has antifungal activity.
Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

Leistungsmerkmale und Vorteile

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Sigma-Aldrich

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Sigma-Aldrich

SML2473

Pitavastatin calcium

Lovastatin Lovastatin, CAS 75330-75-5, is an anti-hypercholesterolemic agent that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.

Sigma-Aldrich

438185

Lovastatin

Mevastatin ≥98% (HPLC), powder or crystals

Sigma-Aldrich

M2537

Mevastatin

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Sigma-Aldrich

C6895

Cefaclor

Simvastatin analytical standard

Supelco

38956

Simvastatin

Atorvastatin Hemicalciumsalz Sesquihydrat Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1422

Atorvastatin Hemicalciumsalz Sesquihydrat

Piroxicam ≥98% (TLC)

Sigma-Aldrich

P5654

Piroxicam

Kazuho Sakamoto et al.
The Journal of pharmacology and experimental therapeutics, 338(1), 62-69 (2011-04-07)
HMG-CoA reductase inhibitor statins are used for the treatment of hypercholesterolemia. However, statins have adverse effects on skeletal muscles with unknown mechanism. We have reported previously that fluvastatin induced vacuolation and cell death in rat skeletal myofibers by depleting geranylgeranylpyrophosphate
Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway
Son SM, et al.
Mol. Neurodegener., 10(1), 56-56 (2015)
Inhibition of mevalonate pathway prevents adipocyte browning in mice and men by affecting protein prenylation
Balaz M, et al.
Cell Metabolism, 29(4), 901-916 (2019)
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-beta in iPSC-Derived Alzheimer?s Disease Neurons
van der Kant R, et al.
Cell Stem Cell, 24(3), 363-375 (2019)
Erica Españo et al.
Scientific reports, 9(1), 11461-11461 (2019-08-09)
Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family. ZIKV infection has been associated with neurological complications such as microcephaly in newborns and Guillain-Barré syndrome in adults; thus, therapeutic agents are urgently needed. Statins are clinically approved for
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Artikel

Antilipemic Agents

Randomized controlled clinical studies have suggested 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are effective in both primary and secondary prevention of cardiovascular disease (CVD) events.

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