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SML1264

Sigma-Aldrich

Rosuvastatin calcium

≥98% (HPLC)

Synonym(e):

(E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrim idin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid, calcium salt (2:1), Rosuvastatin hemicalcium

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About This Item

Empirische Formel (Hill-System):
C22H27FN3O6S · 0.5 Ca
CAS-Nummer:
147098-20-2
Molekulargewicht:
500.57
UNSPSC-Code:
12352200
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Optische Aktivität

[α]/D +12 to +18°, c = 1 in methanol: water (1:1)

Lagerbedingungen

desiccated

Farbe

white to beige

Löslichkeit

DMSO: 10 mg/mL, clear

Lagertemp.

2-8°C

InChI

1S/2C22H28FN3O6S.Ca/c2*1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32;/h2*5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30);/q;;+2/p-2/b2*10-9+;/t2*16-,17-;/m11./s1

InChIKey

LALFOYNTGMUKGG-BGRFNVSISA-L

Allgemeine Beschreibung

Rosuvastatin calcium (ROS) has a molecular mass of 1001.14. ROS is a member of the "statins" group and is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.

Anwendung

Rosuvastatin calcium has been used to determine the effect of the treatment with SIM, rosuvastatin or PRA on cholesterol and HMGCR levels in HeLa cells and to evaluate the in vivo effects of statins on glucose homeostasis.

Biochem./physiol. Wirkung

Rosuvastatin calcium is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin calcium is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Atorvastatin-Calcium United States Pharmacopeia (USP) Reference Standard

USP

1044516

Atorvastatin-Calcium

Atorvastatin Hemicalciumsalz Sesquihydrat Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1422

Atorvastatin Hemicalciumsalz Sesquihydrat

Olmesartan ≥98% (HPLC)

Sigma-Aldrich

SML1394

Olmesartan

Cerivastatin sodium salt hydrate ≥98% (HPLC)

Sigma-Aldrich

SML0005

Cerivastatin sodium salt hydrate

USP

USP

1606048

Rosuvastatin Related Compound C

Fluvastatin Natrium European Pharmacopoeia (EP) Reference Standard

Y0001090

Fluvastatin Natrium

USP

USP

1554206

Pravastatinnatrium

Fluvastatin Natrium United States Pharmacopeia (USP) Reference Standard

USP

1285931

Fluvastatin Natrium

Analytical Methods for the Determination of Rosuvastatin in Pharmaceutical Formulations and Biological Fluids: A Critical Review.
Angelo ML, et al.
Critical Reviews in Analytical Chemistry, 48(4), 317-329 (2018)
Chronic HMGCR/HMG-CoA reductase inhibitor treatment contributes to dysglycemia by upregulating hepatic gluconeogenesis through autophagy induction.
Wang HJ, et al.
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HPLC methods for recently approved pharmaceuticals (2005)
Colin H Beckwitt et al.
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Statins are cholesterol-depleting drugs used to treat patients with hypercholesterolemia. Preclinically, statins disrupt trafficking of receptors present at the cell membrane. Membrane receptors, defined as tumor biomarkers and therapeutic targets, are often internalized by an endocytic pathway. Indeed, receptor endocytosis
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