Direkt zum Inhalt
Merck
Alle Fotos(1)

Dokumente

C6895

Sigma-Aldrich

Cefaclor

Synonym(e):

7-(D-2-Amino-2-phenylacetamido)-3-chloro-3-cephem-4-carboxylic acid

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

Empirische Formel (Hill-System):
C15H14ClN3O4S
CAS-Nummer:
53994-73-3
Molekulargewicht:
367.81
Beilstein:
8176092
EG-Nummer:
258-909-5
MDL-Nummer:
MFCD00151471
UNSPSC-Code:
51101500
PubChem Substanz-ID:
24278331
NACRES:
NA.85

Form

powder or crystals

Qualitätsniveau

200

Löslichkeit

soluble (slightly soluble in water, practically insoluble in methanol, ethanol)

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria

Wirkungsweise

cell wall synthesis | interferes

SMILES String

N[C@@H](C(=O)N[C@H]1[C@H]2SCC(Cl)=C(N2C1=O)C(O)=O)c3ccccc3

InChI

1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1

InChIKey

QYIYFLOTGYLRGG-GPCCPHFNSA-N

Suchen Sie nach ähnlichen Produkten? Aufrufen Leitfaden zum Produktvergleich

Verwandte Kategorien

Allgemeine Beschreibung

Chemical structure: ß-lactam

Anwendung

Cefaclor has been used in the heterologous expression of AaOr7 and AaOr8 in Xenopus laevis oocytes. It has also been used in cultures of isolated trigeminal ganglion (TG) and dorsal root ganglion (DRG) neurons.
Cefaclor is used to study urinary tract, intra-abdominal, and Haemophilus influenzae infections . It is used to study the mechanism of human renal organic anion and peptide transporters such as hOAT1, hPEPT1, and hPEPT2 and to study the effects of inhibition of penicillin-binding proteins on bacterial cell wall mucopeptide synthesis .

Biochem./physiol. Wirkung

Cefaclor is a second generation cephalosporin with broad spectrum activity against Gram-negative and Gram-positive bacteria. It binds to penicillin-binding proteins and thereby inhibits the cell wall synthesis causing cell death.

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place. Slightly soluble in water, practically insoluble in methanol, chloroform and benzene.

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Kunden haben sich ebenfalls angesehen

Slide 1 of 6

1 of 6

Ceftibuten hydrate ≥98% (HPLC)

Sigma-Aldrich

SML0037

Ceftibuten hydrate

Cefuroxim Natriumsalz

Supelco

C4417

Cefuroxim Natriumsalz

Cinoxacin

Sigma-Aldrich

C8645

Cinoxacin

7-Aminocephalosporansäure 98%

Sigma-Aldrich

191140

7-Aminocephalosporansäure

Phenoxymethylpenicillin European Pharmacopoeia (EP) Reference Standard

P1000000

Phenoxymethylpenicillin

vibrant-m

Y0000633

Cefepim -dihydrochlorid Monohydrat

C O Onyeji et al.
Antimicrobial agents and chemotherapy, 38(5), 1112-1117 (1994-05-01)
The duration of time that serum drug levels remain above the MIC (time above the MIC) for the pathogen has been shown to be the most significant parameter determining the efficacies of beta-lactam antibiotics. In the described study, we investigated
Kiran Singh et al.
European journal of medicinal chemistry, 42(3), 394-402 (2007-01-17)
A few (1:1) and (1:2) metal complexes of cobalt(II), nickel(II), copper(II) and zinc(II) have been isolated with ligand derived from the condensation of 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine with 2-acetylpyridine (L(1)) and characterized by elemental analysis, conductivity measurements, infrared, electronic, (1)H NMR spectral data
Meng Li et al.
Drug metabolism and disposition: the biological fate of chemicals, 34(4), 547-555 (2006-01-26)
Amoxicillin and cefaclor are two of the widely used beta-lactam antibiotics in the treatment of urinary tract infections. Both drugs are eliminated mainly by the kidney and rely on renal excretion to exert their antibacterial activities in the urinary tract.
C A Webster et al.
The Journal of antimicrobial chemotherapy, 38(1), 59-66 (1996-07-01)
Insusceptibility levels of cefaclor and other commonly prescribed antibiotics were determined for 489 consecutive hospital and community-associated urinary tract isolates of Escherichia coli from the Nottingham area of the UK. Significant resistance (MIC of > or = 8 mg/L) to
Nikita B Ruparel et al.
Journal of endodontics, 38(10), 1372-1375 (2012-09-18)
Regenerative endodontic procedures are an alternative treatment for immature teeth with necrotic pulps. Typically, intracanal medicaments such as triple antibiotic paste (TAP) or double antibiotic paste (DAP) and calcium hydroxide (Ca[OH](2)) are used for disinfection. However, their effect on human
Alle zugehörigen Dokumente anzeigen

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.