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PHR1524

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Tamsulosin-Hydrochlorid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

Tamsulosin -hydrochlorid, 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)-ethyl]-amino]-propyl]-2-methoxybenzolsulfonamid -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C20H28N2O5S · HCl
CAS-Nummer:
106463-17-6
Molekulargewicht:
444.97
MDL-Nummer:
MFCD00922997
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329823437

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

300

Agentur

traceable to BP 876
traceable to Ph. Eur. Y0000650
traceable to USP 1643260

API-Familie

tamsulosin

Analysenzertifikat (CofA)

current certificate can be downloaded

Verpackung

ampule of 1 × 200 mg

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

-10 to -25°C

SMILES String

Cl.CCOc1ccccc1OCCN[C@H](C)Cc2ccc(OC)c(c2)S(N)(=O)=O

InChI

1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1

InChIKey

ZZIZZTHXZRDOFM-XFULWGLBSA-N

Angaben zum Gen

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

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Verwandte Kategorien

Allgemeine Beschreibung

Tamsulosin hydrochloride is a subtypeselective a1A and a1D adrenoceptor antagonist, which exists in two enantiomeric forms, of which the R-isomer is the pharmaceutically active component. It is used to reduce urinary obstruction and is also involved in relieving the symptoms associated with symptomatic benign prostatic hyperplasia.

Anwendung

Tamsulosin hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Tamsulosin ist ein α1A/1D-Adrenozeptor-Antagonist, der bei der Behandlung von BPH (benigner Prostatahyperplasie) verwendet wird. Seine Wirkung als α-Blocker beinflusst auch die Iris und führt zu Komplikationen bei Operationen am Grauen Star, bekannt als "Floppy Iris Syndrom".

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAC0288 in the slot below. This is an example certificate only and may not be the lot that you receive.

Empfohlene Produkte

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Ähnliches Produkt

Produkt-Nr.
Beschreibung
Preisangaben

Y0000650

Tamsulosin -hydrochlorid, European Pharmacopoeia (EP) Reference Standard

Y0000653

Tamsulosin als Racemat, European Pharmacopoeia (EP) Reference Standard

Y0000651

Tamsulosin Unreinheit D, European Pharmacopoeia (EP) Reference Standard

Y0000652

Tamsulosin Unreinheit H, European Pharmacopoeia (EP) Reference Standard

1643260

Tamsulosin -hydrochlorid, United States Pharmacopeia (USP) Reference Standard

1643281

Racemisches Tamsulosinhydrochlorid, United States Pharmacopeia (USP) Reference Standard

BP876

Tamsulosin -hydrochlorid, British Pharmacopoeia (BP) Reference Standard

BP877

Tamsulosinhydrochlorid-Unreinheit Standard, British Pharmacopoeia (BP) Reference Standard

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number
LRAC7889
LRAC0288
LRAC0156
LRAA3642

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Validated stability indicating HPTLC method for the determination of Tamsulosin hydrochloride in pharmaceutical dosage forms
Choudhari.PV and Nikalje GPA
International Journal of ChemTech Research, 2(1), 646-652 (2010)
Development and validation of stability-indicating HPTLC determination of tamsulosin in bulk and pharmaceutical dosage form
Bari.BS, et al.
Chromatography Research International, 2011(2), 197-205 (2011)
Validated RP-HPLC and TLC methods for simultaneous estimation of tamsulosin hydrochloride and finasteride in combined dosage forms
Patel B.D and Patel J.N
Acta pharmaceutica, 60(2), 197-205 (2010)

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