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BP1210

Ritonavir

British Pharmacopoeia (BP) Reference Standard

Synonym(s):

1,3-Thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate

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About This Item

Empirical Formula (Hill Notation):
C37H48N6O5S2
CAS Number:
155213-67-5
Molecular Weight:
720.94
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

Quality Level

100

agency

BP

API family

ritonavir

form

solid

shelf life

limited shelf life, expiry date on the label

packaging

pkg of 100 mg

manufacturer/tradename

BP

storage condition

dry at room temperature

color

off-white

mp

122-126  °C

solubility

ethanol: soluble
isopropanol: soluble
methanol: soluble

density

1.239 g/cm3 at 20 °C

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1

InChI key

NCDNCNXCDXHOMX-XGKFQTDJSA-N

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General description

Ritonavir belongs to the group of protease inhibitors that are widely used in combination with other drugs in the prevention of HIV. Its mode of action involves binding to the active site of the protease enzyme and preventing the further maturation of new viral particles.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ritonavir BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Ritonavir Oral Solution
  • Ritonavir Tablets

    • Packaging

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Other Notes

    Sales restrictions may apply.

    pictograms

    Exclamation mark
    GHS07

    signalword

    Warning

    Hazard Classifications

    Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

    wgk_germany

    WGK 3

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

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    RP-HPLC method development and validation for simultaneous estimation of Lopinavir and Ritonavir in tablet dosage form
    Bindu MJ, et al.
    International Journal of Science and Engineering Applications, 5(1), 77-77 (2017)
    HPTLC method for simultaneous determination of lopinavir and ritonavir in capsule dosage form
    Sulebhavikar VA, et al.
    Journal of Chemistry, 5(4), 706-712 (2008)

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