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05-1066

Sigma-Aldrich

Anti-Insulin Antibody, clone E11D7

clone E11D7, from mouse

Synonym(s):

Anti-IDDM, Anti-IDDM1, Anti-IDDM2, Anti-ILPR, Anti-IRDN, Anti-MODY10, Anti-PNDM4

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

E11D7, monoclonal

species reactivity

human

species reactivity (predicted by homology)

rat, mouse

packaging

antibody small pack of 25 μg

technique(s)

ELISA: suitable
immunohistochemistry: suitable (paraffin)

isotype

IgG1κ

NCBI accession no.

NM_000207.2

UniProt accession no.

P01308

shipped in

ambient

target post-translational modification

unmodified

Gene Information

human ... INS(3630)
mouse ... Ins1(16333)
rat ... Ins1(24505)

Related Categories

General description

Insulin is a polypeptide hormone that regulates carbohydrate metabolism. Apart from being the primary agent in carbohydrate homeostasis, it has effects on fat metabolism.

Specificity

Recognizes insulin

Immunogen

Epitope: Insulin
Human recombinant Insulin

Application

Anti-Insulin Antibody, clone E11D7 detects level of Insulin & has been published & validated for use in ELISA, IH(P).
ELISA (Direct) Analysis:
Insulin-coated plate was incubated with Anti-Insulin, clone E11D7 in 2-fold serial dilutions diluted in PBST from 5 μg/mL to 0.01 μg/mL.
Research Category
Signaling

Metabolism
Research Sub Category
Insulin/Energy Signaling

Glucose/Glycogen Metabolism

Metabolic Hormones & Receptors

Quality

Immunohistochemistry Analysis:
20 μg/mL of this antibody detected insulin in β cells.

Target description

6 kDa

Physical form

Format: Purified
Protein G Purified
Purified mouse monolconal IgG1κ in 0.1M Tris-Glycine (pH7.4), 150mM NaCl with 0.05%NaN3

Storage and Stability

Stable for 1 year at 2-8ºC from date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Activation of PPAR? up-regulates the expression of insulin gene transcription factor MafA and ameliorates glucose-induced insulin secretion impaired by palmitate.
Mingming Cao,Yang Long,Yuzhen Tong,Jun Wan,Nanwei Tong
Molecular and Cellular Biochemistry null
Gabriel Cao et al.
PloS one, 16(6), e0243340-e0243340 (2021-06-12)
The objective of this work was to analyze the structural changes of the pancreatic islets in rats, after 6 month consuming regular and light cola for 6 months. Also, we have analyzed the possible role of PDX-1 in that process.
Mi Ran Choi et al.
Journal of ginseng research, 41(4), 503-512 (2017-10-13)
Chronic heavy alcohol consumption may raise the risk of developing type 2 diabetes mellitus. Saponins inhibit apoptosis of pancreatic islet cells and reduce lipid parameters. The present study was designed to investigate the effect of saponin on chronic ethanol-treated diabetic
Daniel Neumeier et al.
European journal of immunology, 52(2), 297-311 (2021-11-03)
Plasma cells and their secreted antibodies play a central role in the long-term protection against chronic viral infection. However, due to experimental limitations, a comprehensive description of linked genotypic, phenotypic, and antibody repertoire features of plasma cells (gene expression, clonal

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