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QBD10198

Sigma-Aldrich

NHS-dPEG®12-biotin

Synonym(s):

NHS-PEG Linker, Polyethylene glycol

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About This Item

Empirical Formula (Hill Notation):
C41H72N4O18S
Molecular Weight:
941.09
UNSPSC Code:
12161502
PubChem Substance ID:
329823889
NACRES:
NA.22

assay

>90%

form

solid or viscous liquid

reaction suitability

reagent type: cross-linking reagent
reaction type: Biotinylations
reactivity: amine reactive

polymer architecture

shape: linear
functionality: monofunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCCC1C2NC(NC2CS1)=O)=O)ON3C(CCC3=O)=O

Related Categories

Features and Benefits

NHS-dPEG®12-biotin is used extensively to label molecules that contain a free amine with biotin. The single molecular weight NHS-dPEG®12-biotin has a long spacer of precise length (47.6 Å) between the biotin moiety and the labeled molecule. This dPEG® spacer imparts a high degree of water solubility to the biotin label. For biotinylated peptides and proteins, the dPEG® spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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