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BP617

Aspirin

British Pharmacopoeia (BP) Reference Standard

Synonym(s):

Acetylsalicylic acid, 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Aspirin

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About This Item

Linear Formula:
2-(CH3CO2)C6H4CO2H
CAS Number:
50-78-2
Molecular Weight:
180.16
Beilstein:
779271
EC Number:
200-064-1
MDL number:
MFCD00002430
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

aspirin

form

crystalline

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

mp

134-136 °C (lit.)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

storage temp.

2-8°C

SMILES string

CC(=O)Oc1ccccc1C(O)=O

InChI

1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)

InChI key

BSYNRYMUTXBXSQ-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742) , PTGS2(5743)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Aspirin BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Aspirin Tablets
  • Aspirin Gastro-resistant Tablets
  • Co-codaprin Tablets
  • Aspirin Dispersible Tablets
  • Aspirin and Caffeine Tablets

    • Biochem/physiol Actions

    Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

    Packaging

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Other Notes

    Sales restrictions may apply.

    related product

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    PHR1003

    Aspirin (Acetyl Salicylic Acid), Pharmaceutical Secondary Standard; Certified Reference Material

    1044006

    Aspirin, United States Pharmacopeia (USP) Reference Standard

    A0200000

    Acetylsalicylic acid, European Pharmacopoeia (EP) Reference Standard

    Y0001460

    Acetylsalicylic acid for peak identification, European Pharmacopoeia (EP) Reference Standard

    1609807

    Salsalate, United States Pharmacopeia (USP) Reference Standard

    1696200

    Trisalicylic acid, United States Pharmacopeia (USP) Reference Standard

    PHR1940

    Aspirin Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material

    PHR1941

    Aspirin Impurity E, Pharmaceutical Secondary Standard; Certified Reference Material

    PHR1942

    Aspirin Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

    Pictograms

    Exclamation mark
    GHS07

    Signal Word

    Warning

    Hazard Statements

    H302

    Precautionary Statements

    P264 - P270 - P301 + P312 - P501

    Hazard Classifications

    Acute Tox. 4 Oral

    WGK

    WGK 1

    Flash Point(F)

    482.0 °F

    Flash Point(C)

    250 °C

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    Certificates of Analysis (COA)

    Lot/Batch Number

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    Silica mesoporous, 0.5 μm particle size, pore size ~2 nm

    Sigma-Aldrich

    805890

    Silica

    Acetic anhydride Arxada quality, ≥99.5% (GC)

    Sigma-Aldrich

    691275

    Acetic anhydride

    Aspirin Impurity F Pharmaceutical Secondary Standard; Certified Reference Material

    Supelco

    PHR1942

    Aspirin Impurity F

    Phosphoric acid solution 85 wt. % in H2O, FCC, FG

    Sigma-Aldrich

    W290017

    Phosphoric acid solution

    Salicylic acid BioXtra, ≥99.0%

    Sigma-Aldrich

    S5922

    Salicylic acid

    Validated ultra HPLC method for the simultaneous determination of atorvastatin, aspirin, and their degradation products in capsules.
    Vora D N, et al.
    Journal of Liquid Chromatography and Related Technologies, 31(18), 2821-2837 (2008)
    RP-HPLC analysis of aspirin and clopidogrel bisulphate in combination.
    An K, et al.
    Indian Journal of Pharmaceutical Sciences, 69(4), 597-597 (2007)

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