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PHR1005

Supelco

Acetaminophen

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

4′-Hydroxyacetanilide, 4-Acetamidophenol, N-(4-Hydroxyphenyl)acetamide, N-Acetyl-4-aminophenol, APAP, Paracetamol

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About This Item

Linear Formula:
CH3CONHC6H4OH
CAS Number:
103-90-2
Molecular Weight:
151.16
Beilstein:
2208089
EC Number:
203-157-5
MDL number:
MFCD00002328
UNSPSC Code:
41116107
PubChem Substance ID:
329823036
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 371
traceable to Ph. Eur. P030000
traceable to USP 1003009

API family

paracetamol, acetaminophen

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

168-172 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CC(=O)Nc1ccc(O)cc1

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

InChI key

RZVAJINKPMORJF-UHFFFAOYSA-N

Gene Information

human ... FAAH(2166) , PTGS1(5742) , PTGS2(5743) , TRPV1(7442)

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Related Categories

General description

Acetaminophen is a drug, which possesses pharmacological properties like antipyretic and analgesic property.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Acetaminophen may be used as a standard in the determination of acetaminophen in human serum or plasma samples using spectrophotometric technique. It may also be used as a standard in the estimation of acetaminophen in pharmaceutical formulations using high performance liquid chromatography (HPLC).
Analgesic.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7782 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.
Description
Pricing

PHR1148

4-Aminophenol (Acetaminophen Related Compound K) (Paracetamol Impurity K), Pharmaceutical Secondary Standard; Certified Reference Material

PHR1149

Acetaminophen Related Compound J, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1150

Acetaminophen Related Compound F, Pharmaceutical Secondary Standard; Certified Reference Material

1003009

Acetaminophen, United States Pharmacopeia (USP) Reference Standard

1021204

4-Aminophenol, United States Pharmacopeia (USP) Reference Standard

PHR1225

3-Aminophenol, Pharmaceutical Secondary Standard; Certified Reference Material

1003010

Acetaminophen Related Compound A, United States Pharmacopeia (USP) Reference Standard

P0300000

Paracetamol, European Pharmacopoeia (EP) Reference Standard

PHR1612

Acetaminophen Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

1003027

Acetaminophen Related Compound B, United States Pharmacopeia (USP) Reference Standard

1003100

Acetaminophen Related Compound J, United States Pharmacopeia (USP) Reference Standard

PHR1642

Acetaminophen Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

1003064

Acetaminophen Related Compound F, United States Pharmacopeia (USP) Reference Standard

1026004

m-Aminophenol, United States Pharmacopeia (USP) Reference Standard

Y0001781

Paracetamol for equipment qualification, European Pharmacopoeia (EP) Reference Standard

BP371

Paracetamol, British Pharmacopoeia (BP) Reference Standard

Y0001945

Paracetamol impurity J, European Pharmacopoeia (EP) Reference Standard

Y0001955

Paracetamol impurity K, European Pharmacopoeia (EP) Reference Standard

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

364.3 °F - Pensky-Martens closed cup

Flash Point(C)

184.6 °C - Pensky-Martens closed cup

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC6466
LRAD4560
LRAB7782
LRAC2955
LRAB3711

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Simultaneous high-performance liquid chromatographic stability-indicating analysis of acetaminophen and codeine phosphate in tablets and capsules
Sisco.RW, et al.
Journal of Chromatography A, 348, 253-263 (1985)
Spectrophotometric Screening Method for Acetaminophen in Serum and Plasma
Liu.ZT and Oka.HK
Clinical Chemistry, 26, 69-71 (1980)
Reversed-phase HPLC method for the estimation of acetaminophen, ibuprofen and chlorzoxazone in formulations
Ravisankar.S, et al.
Talanta, 46, 1577-1581 (1998)
S M de Morais et al.
Gastroenterology, 102(2), 577-586 (1992-02-01)
Gilbert's syndrome occurs in 5%-7% of the human population and is caused by an inherited deficiency in the glucuronidation of endogenous bilirubin, resulting in its accumulation and jaundice. The authors of the present study have previously shown that rats with
Edward Munsterhjelm et al.
Anesthesiology, 103(4), 712-717 (2005-09-30)
Acetaminophen (paracetamol) is widely used for postoperative analgesia. Its mechanism of action is inhibition of prostaglandin synthesis in the central nervous system, and acetaminophen is traditionally not considered to influence platelet function. The authors studied the dose-dependent inhibition of platelet
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