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Supelco

Tazobactam sodium salt

analytical standard

Synonym(s):

CL-298741, YTR-830H, [2S-(2α, 3β, 5α)]-3-Methyl-7-oxo-3(1H,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide

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About This Item

Empirical Formula (Hill Notation):
C10H11N4NaO5S
CAS Number:
Molecular Weight:
322.27
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

Assay

≥98.0% (HPLC)

optical activity

[α]/D 144±4°, c = 0.1 in H2O

shelf life

limited shelf life, expiry date on the label

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[Na+].C[C@]2(Cn1ccnn1)[C@@H](N3[C@@H](CC3=O)S2(=O)=O)C([O-])=O

InChI

1S/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m1./s1

InChI key

RFMIKMMOLPNEDG-QVUDESDKSA-M

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General description

Tazobactam sodium is the sodium salt of the β-lactamase inhibitor antibiotic, tazobactam. It is a semisynthetic parenteral penicillin which can be combined with piperacillin and ceftolozane drugs for treating a variety of infections.

Application

Tazobactam sodium may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by reversed-phase high-performance liquid chromatography.

Recommended products

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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USP

USP

1541500

Piperacillin

Ceftazidime hydrate 90.0-105.0%, contains ~10% sodium carbonate as stabilizer

Sigma-Aldrich

C3809

Ceftazidime hydrate

Imipenem monohydrate ≥98% (HPLC)

Sigma-Aldrich

I0160

Imipenem monohydrate

L-Cystathionine ≥98% (TLC)

Sigma-Aldrich

C7505

L-Cystathionine

Meropenem trihydrate ≥98% (HPLC)

Sigma-Aldrich

M2574

Meropenem trihydrate

Meropenem Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1772

Meropenem

RP-HPLC method for simultaneous estimation of cefepime hydrochloride and tazobactam sodium in bulk and pharmaceuticals
Tamboli SR and Patil DD
Journal of Chemistry, 2013(4), 543-543 (2013)
Stability indicating RP-HPLC method for the estimation of ceftazidime pentahydrate and tazobactam sodium in bulk and dosage forms
Amareswari S, et al.
Indian Journal of Pharmaceutical and Biological Research, 1(4), 543-543 (2013)
RP-HPLC method for simultaneous estimation of cefepime hydrochloride and tazobactam sodium in bulk and pharmaceuticals
Tamboli SR and Patil DD
Journal of Chemistry, 2013(1), 127-131 (2013)

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