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AB15415

Sigma-Aldrich

Anti-GABARAP Antibody

serum, Chemicon®

Synonym(s):

Gamma-aminobutyric acid receptor-associated protein, GABA(A) receptor-associated protein

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, rat

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_007278.1

UniProt accession no.

O95166

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... GABARAP(11337)

General description

Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. An important inhibitory neurotransmitter, GABA, acts on GABA receptors that are ubiquitously expressed in the CNS. GABARAP has been shown to play a important role in modulating the activities of GABA (A) receptors.

Specificity

GABARAP [Gamma-aminobutyric acid receptor-associated protein, GABA(A) receptor-associated protein].

Immunogen

Synthetic peptide corresponding to a region within the N-terminus of human GABARAP protein.

Application

Anti-GABARAP Antibody detects level of GABARAP & has been published & validated for use in IC, IH & WB.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Western blot: 1:100-1:1,000
Immunocytochemistry: 1:100-1:1,000
Immunohistochemistry: 1:100-1:1,000
Optimal working dilutions must be determined by end user.

Physical form

Lyophilized. Reconstitute with 50 uL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative.
Serum

Storage and Stability

Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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GABAA receptor associated proteins: a key factor regulating GABAA receptor function.
Chen, Zi-Wei and Olsen, Richard W
Journal of Neurochemistry, 100, 279-294 (2007)
Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation.
Iwata, Atsushi, et al.
Proceedings of the National Academy of Sciences of the USA, 102, 13135-13140 (2005)

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