890705P
Avanti
16:0-18:1 EPC (Cl Salt)
Avanti Polar Lipids 890705P, powder
Synonym(s):
1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (chloride salt)
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C44H87NO8PCl
CAS Number:
Molecular Weight:
824.59
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
form
powder
packaging
pkg of 1 × 10 mg (890705P-10mg)
pkg of 1 × 25 mg (890705P-25mg)
manufacturer/tradename
Avanti Polar Lipids 890705P
application(s)
advanced drug delivery
lipid type
transfection
cationic lipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)OCC.[Cl-]
General description
1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (16:0-18:1 EPC) is cationic lipid containing an ethyl group attached to the phosphate moiety through an ester bond and has a choline headgroup.
Application
1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (chloride salt) (16:0-18:1 EPC (Cl Salt)) might be used:
- as a cationic lipid to explore the change in organization and dynamics of a membrane-bound fluorescent probe in host membranes of varying charge
- in the preparation of small unilamellar cationic liposomes
- in a novel albumin-associated lipoplex formulation to evaluate the antitumoral efficacy of immuno-gene therapy and “suicide” gene therapy
Biochem/physiol Actions
1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (16:0-18:1 EPC) is a potential transfection agent, which is also similar to the natural lipids.
Packaging
5 mL Clear Glass Sealed Ampule (890705P-10mg)
5 mL Clear Glass Sealed Ampule (890705P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Marta Passadouro et al.
International journal of nanomedicine, 9, 3203-3217 (2014-07-26)
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and mortal cancer, characterized by a set of known mutations, invasive features, and aberrant microRNA expression that have been associated with hallmark malignant properties of PDAC. The lack of effective PDAC treatment
Wei Zong et al.
Langmuir : the ACS journal of surfaces and colloids, 34(23), 6874-6886 (2018-05-20)
The success of nanoparticulate formulations in drug delivery depends on various aspects including their toxicity, internalization, and intracellular location. Vesicular assemblies consisting of phospholipids and amphiphilic block copolymers are an emerging platform, which combines the benefits from liposomes and polymersomes
Boris G Tenchov et al.
Biochimica et biophysica acta, 1778(10), 2405-2412 (2008-08-30)
Synthetic cationic lipids can be used as DNA carriers and are regarded to be the most promising non-viral gene carriers. For this investigation, six novel phosphatidylcholine (PC) cationic derivatives with various hydrophobic moieties were synthesized and their transfection efficiencies for
Rumiana Koynova et al.
Biochimica et biophysica acta, 1768(2), 375-386 (2006-12-13)
Lipoplexes containing a mixture of cationic phospholipids dioleoylethylphosphatidylcholine (EDOPC) and dilauroylethylphosphatidylcholine (EDLPC) are known to be far more efficient agents in transfection of cultured primary endothelial cells than are lipoplexes containing either lipid alone. The large magnitude of the synergy
Li Wang et al.
Molecular pharmaceutics, 4(4), 615-623 (2007-04-06)
To date, the primary approach to improving the transfection properties of cationic lipids has been the synthesis of new kinds of cationic amphipaths. Recently, however, it was found that combining two cationic lipid derivatives having the same head group but
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service