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810218P

Avanti

C6-NBD Sphingomyelin

Avanti Polar Lipids 810218P, powder

Synonym(s):

N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sphingosine-1-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C35H61N6O9P
CAS Number:
94885-04-8
Molecular Weight:
740.87
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (810218P-1mg)

manufacturer/tradename

Avanti Polar Lipids 810218P

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C35H61N6O9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-18-21-32(42)30(28-49-51(46,47)48-27-26-41(2,3)4)37-33(43)22-19-17-20-25-36-29-23-24-31(40(44)45)35-34(29)38-50-39-35/h18,21,23-24,30,32,42H,5-17,19-20,22,25-28H2,1-4H3,(H2-,36,37,39,43,46,47)/b21-18+/t30-,32+/m0/s1

InChI key

YDBDYTGWMRUUSN-PERJAUJZSA-N

General description

Sphingomyelin is a membrane phospholipid with a central sphingosine and an amide linked fatty acid. Phosphocholine forms the polar head group. It is one of the major phospholipid present in milk fat globule membrane.

Application

C6-NBD sphingomyelin is suitable for endocytosis assay.

Biochem/physiol Actions

Sphingomyelin controls cell growth, differentiation, apoptosis and signal transduction along the membrane. It is known to prevent the proliferation of colon tumour. Sphingomyelin also inhibits cholesterol absorption. Abnormal accumulation of sphingomyelin causes Niemann Pick disease.

Packaging

5 mL Amber Glass Screw Cap Vial (810218P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Apoptosis: Biology and Mechanisms, 66-66 (2013)
Bioactive Components of Milk, 22-22 (2007)
mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery
Dauner K, et al.
The Journal of biological chemistry, 292(14), 5737-5747 (2017)
Mark L Schultz et al.
BMC medicine, 17(1), 200-200 (2019-11-13)
Niemann-Pick disease type C is a fatal and progressive neurodegenerative disorder characterized by the accumulation of unesterified cholesterol in late endosomes and lysosomes. We sought to develop new therapeutics for this disorder by harnessing the body's endogenous cholesterol scavenging particle
Avery L McIntosh et al.
Lipids, 45(6), 465-477 (2010-05-18)
During the last several years, intracellular lipid droplets have become the focus of intense study. No longer an inert bystander, the lipid droplet is now known as a dynamic organelle contributing lipids to many cellular events. However, while the dynamics

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