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S2647

Sigma-Aldrich

Spectinomycin -dihydrochlorid Pentahydrat

powder, γ-irradiated

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About This Item

Empirische Formel (Hill-System):
C14H24N2O7 · 2HCl · 5H2O
CAS-Nummer:
22189-32-8
Molekulargewicht:
495.35
EG-Nummer:
244-554-3
MDL-Nummer:
MFCD00150886
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24899532
NACRES:
NA.85

Biologische Quelle

synthetic (inorganic)

Qualitätsniveau

200

Qualität

for molecular biology

Sterilität

γ-irradiated

Form

powder

Wirksamkeit

≥500 μg per mg

Lagerbedingungen

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

Farbe

white to off-white

Löslichkeit

H2O: soluble at 

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria

Wirkungsweise

protein synthesis | interferes

Lagertemp.

2-8°C

Eignung

nonselective for Escherichia coli
nonselective for coliforms

SMILES String

O.O.O.O.O.Cl.Cl.CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O

InChI

1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1

InChIKey

DCHJOVNPPSBWHK-UXXUFHFZSA-N

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Allgemeine Beschreibung

Chemical structure: aminoglycoside

Anwendung

Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. It is recommended for use in cell culture applications at 7.5-20 mg/L.

Biochem./physiol. Wirkung

Wirkungsweise: Spectinomycin wirkt durch Hemmung der Proteinsynthese und -verlängerung, indem es an die bakterielle 30S-Ribosomen-Untereinheit bindet und in die Peptidyl-tRNA-Translokation eingreift.

Resistenzmethode: Eine Mutation in rpsE, dem Gen für das ribosomale Protein S5, verhindert die Bindung von Spectinomycin. Resistenz erfolgt auch durch das Aminoglykosid-3-′-Adenyltransferase-Gen (aadA).

Antimikrobielles Spektrum: Spectinomycin wirkt gegen gramnegative und grampositive Bakterien.

Verpackung

100MG

Vorsicht

Solutions can be stored at 2-8°C for several weeks or at -20°C for more extended periods.

Angaben zur Herstellung

Stock solutions should be prepared at 10 mg/mL in water and filter sterilized.

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

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Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Journal of bacteriology, 180(1), 100-106 (1998-01-09)
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