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S9137

Sigma-Aldrich

Streptomycin -sulfat (Salz)

powder, BioReagent, suitable for cell culture

Synonym(e):

Streptomycin, Streptomycin Sulphate

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About This Item

Lineare Formel:
C21H39N7O12 · 1.5 H2SO4
CAS-Nummer:
3810-74-0
Molekulargewicht:
728.69
Beilstein:
3894995
EG-Nummer:
223-286-0
MDL-Nummer:
MFCD00037023
UNSPSC-Code:
51101500
PubChem Substanz-ID:
24899828
NACRES:
NA.76

Produktlinie

BioReagent

Qualitätsniveau

200

Form

powder

Wirksamkeit

≥720 I.U. per mg (dried basis)

Lagerbedingungen

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

Methode(n)

cell culture | mammalian: suitable

Farbe

white to off-white

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

Wirkungsweise

protein synthesis | interferes

Lagertemp.

2-8°C

SMILES String

OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N

InChI

1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1

InChIKey

QTENRWWVYAAPBI-YZTFXSNBSA-N

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Allgemeine Beschreibung

Chemical structure: aminoglycoside

Anwendung

Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.

Biochem./physiol. Wirkung

Wirkungsweise: Streptomycin wirkt durch die Hemmung der Prokaryoten-Proteinsynthese, indem es an das S12-Protein der 30S-Untereinheit des Ribosoms bindet und dadurch die Translation vom Initiationskomplex zum kettenverlängernden Ribosom verhindert. Dadurch entsteht eine Fehlcodierung bzw. die Initiation wird gehemmt.

Widerstandsmechanismus: Eine Mutation in rpsL, einem Gen für das ribosomale Protein S12, verhindert die Bindung von Streptomycin an das Ribosom. Durch eine Aminoglycosid-Phosphotransferase wird Streptomycin ebenfalls inaktiviert.

Antimikrobielles Spektrum: Streptomycin wirkt gegen gramnegative und grampositive Bakterien.

Vorsicht

Solutions can be stored at 2-8°C for up to a month or at -20°C for more extended periods. At 37°C, solutions are stable for three days.

Angaben zur Herstellung

Stock solutions should be prepared directly in the vial with sterile water at concentrations between 20-25 mg/mL.

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

Piktogramme

Health hazardExclamation mark
GHS08,GHS07

Signalwort

Warning

H-Sätze

H302,H361fd

Gefahreneinstufungen

Acute Tox. 4 Oral - Repr. 2

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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