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M5255

Sigma-Aldrich

Mycophenolsäure

from Penicillium brevicompactum, ≥98% (HPLC), powder, IMP dehydrogenase inhibitor

Synonym(e):

6-(1,3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxo-isobenzofuran-6-yl)-4-methyl-4-hexensäure

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About This Item

Empirische Formel (Hill-System):
C17H20O6
CAS-Nummer:
24280-93-1
Molekulargewicht:
320.34
Beilstein:
1295848
EG-Nummer:
246-119-3
MDL-Nummer:
MFCD00036814
UNSPSC-Code:
12352106
PubChem Substanz-ID:
24896987
NACRES:
NA.77

product name

Mycophenolsäure, ≥98%

Biologische Quelle

Penicillium brevicompactum

Qualitätsniveau

300

Assay

≥98%

Farbe

white to yellow-white

mp (Schmelzpunkt)

<143.0 °C

Löslichkeit

methanol: 49.00-51.00 mg/mL, clear, colorless to faintly yellow

Wirkungsweise

enzyme | inhibits

Ersteller

Novartis

Lagertemp.

2-8°C

SMILES String

COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O

InChI

1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+

InChIKey

HPNSFSBZBAHARI-RUDMXATFSA-N

Angaben zum Gen

human ... IMPDH1(3614) , IMPDH2(3615)

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Anwendung

Mycophenolic acid (MPA), produced by Penicillum brevi-compactum, is a selective inhibitor of inosine monphosphate dehydrogenase, thus inhibiting DNA synthesis in T and B lymphocytes. It has also been shown to act as an immunosuppressive agent, and as an inducer of monocyte differentiation and apoptosis in human lymphoid and monocytic cell lines. As a selection agent, MPA is used for transfected animal cells expressing the E. Coli gene for xanthine-guanine phosphoribosyl transferase, and is recommended for use at 25μg/mL.

Biochem./physiol. Wirkung

Mode of Action: This product acts by suppressing the cytokine-induced nitric oxide production, inhibiting early stage biosynthesis of purine nucleotides and as a specific inhibitor of IMP dehydrogenase.

Leistungsmerkmale und Vorteile

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Vorsicht

As supplied, this product should be stored desiccated at 2-8°C, and is stable for 5 years when stored properly.

Angaben zur Herstellung

Mycophenolic acid is soluble in methanol at 50 mg/mL, yielding a colorless to faint yellow solution, as well as chloroform, dichloromethane, ethanol and .1 N NaOH. After reconstitution, the recommendation is to sterilize via filtration thorugh a 0.22 μm pore-size filter, aliquot, and freeze at -20°C.

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Repr. 1B - STOT RE 1 Oral

Zielorgane

Immune system

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Methods for studying activation of matrix metalloproteinases.
V Knäuper et al.
Methods in molecular biology (Clifton, N.J.), 151, 377-387 (2001-02-24)
Burkhard Tönshoff et al.
Transplantation reviews (Orlando, Fla.), 25(2), 78-89 (2011-04-02)
Mycophenolate mofetil (MMF) is widely used for maintenance immunosuppressive therapy in pediatric renal and heart transplant recipients. Children undergo developmental changes (ontogeny) of drug disposition, which may affect drug metabolism of the active compound mycophenolic acid (MPA). Therefore, a detailed
Hylke de Jonge et al.
Therapeutic drug monitoring, 31(4), 416-435 (2009-06-19)
Although therapeutic drug monitoring (TDM) of immunosuppressive drugs has been an integral part of routine clinical practice in solid organ transplantation for many years, ongoing research in the field of immunosuppressive drug metabolism, pharmacokinetics, pharmacogenetics, pharmacodynamics, and clinical TDM keeps
Amy Tarangelo et al.
Life science alliance, 5(4) (2022-01-26)
Nucleotide synthesis is a metabolically demanding process essential for DNA replication and other processes in the cell. Several anticancer drugs that inhibit nucleotide metabolism induce apoptosis. How inhibition of nucleotide metabolism impacts non-apoptotic cell death is less clear. Here, we
Christine E Staatz et al.
Clinical pharmacokinetics, 50(12), 759-772 (2011-11-18)
This review seeks to summarize the available data about Bayesian estimation of area under the plasma concentration-time curve (AUC) and dosage prediction for mycophenolic acid (MPA) and evaluate whether sufficient evidence is available for routine use of Bayesian dosage prediction
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