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L5783

Sigma-Aldrich

Lidocain-N-ethylbromid

analytical standard, for drug analysis

Synonym(e):

N-(2,6-Dimethylphenylcarbamoylmethyl)-triethylammoniumbromid, QX-314

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About This Item

Empirische Formel (Hill-System):
C16H27BrN2O
CAS-Nummer:
21306-56-9
Molekulargewicht:
343.30
MDL-Nummer:
MFCD00083182
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329817630
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

200

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Format

neat

SMILES String

[Br-].CC[N+](CC)(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H

InChIKey

DLHMKHREUTXMCH-UHFFFAOYSA-N

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Anwendung

Lidocaine N-ethyl bromide has been used as a standard in studying the demethylation effect of lidocaine N-ethyl bromide on breast cancer cells in vitro using colorimetric assay.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem./physiol. Wirkung

Ein quaternäres Derivat von Lidocain, das nicht membrandurchlässig ist. Hemmt sowohl schnelle Na+-abhängige Aktionspotentiale und spannungsabhängige, aktivierte Na+ Leitfähigkeit.

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Analysenzertifikate (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

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D P Roberson et al.
British journal of pharmacology, 164(1), 48-58 (2011-04-05)
We have developed a strategy to target the permanently charged lidocaine derivative lidocaine N-ethyl bromide (QX-314) selectively into nociceptive sensory neurons through the large-pore transient receptor potential cation channel subfamily V (TRPV1) noxious heat detector channel. This involves co-administration of
Hossain Md Zakir et al.
PloS one, 7(9), e44023-e44023 (2012-09-11)
Increased expression of the transient receptor potential vanilloid 1 (TRPV1) channels, following nerve injury, may facilitate the entry of QX-314 into nociceptive neurons in order to achieve effective and selective pain relief. In this study we hypothesized that the level
Ricardo E Rivera-Acevedo et al.
Anesthesiology, 114(6), 1425-1434 (2011-04-20)
Transient receptor potential vanilloid subfamily member 1 (TRPV1) channels are important integrators of noxious stimuli with pronounced expression in nociceptive neurons. The experimental local anesthetic, QX-314, a quaternary (i.e., permanently charged) lidocaine derivative, recently has been shown to interact with
Arthur Beyder et al.
Circulation, 125(22), 2698-2706 (2012-05-09)
Na(V)1.5 is a mechanosensitive voltage-gated sodium-selective ion channel responsible for the depolarizing current and maintenance of the action potential plateau in the heart. Ranolazine is a Na(V)1.5 antagonist with antianginal and antiarrhythmic properties. Mechanosensitivity of Na(V)1.5 was tested in voltage-clamped
W G Regehr et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 12(11), 4202-4223 (1992-11-01)
The spatial and temporal dynamics of many electrophysiological and biochemical processes in nerve cells are in turn dependent on the concentration dynamics of the second messenger calcium. We have used microfluorimetry of the calcium indicator fura-2 (Grynkiewicz et al., 1985)
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