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M3821

Sigma-Aldrich

Anti-Myelin Basic Protein (MBP) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-MBP

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About This Item

MDL-Nummer:
MFCD01322361
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

200

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 17-22 kDa (isoform)
antigen ~22 kDa (isoform)
antigen ~33 kDa (isoform)

Speziesreaktivität

rat, human, mouse

Konzentration

~1 mg/mL

Methode(n)

flow cytometry: 1:200-1:500
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000

UniProt-Hinterlegungsnummer

P02686

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... MBP(4155)
mouse ... Mbp(17196)
rat ... Mbp(24547)

Verwandte Kategorien

Allgemeine Beschreibung

Myelin Basic Protein (MBP) is a hydrophilic protein that is expressed mainly in oligodendrocytes. It has a pivotal role in myelination of nervous system, signaling pathways prior to myelination and remyelination processes after neural injury. Anti-myelin basic protein (MBP) antibody can be used in western blotting and flow cytometry. Rabbit anti-myelin basic protein antibody reacts specifically with myelin basic protein of mouse, rat and human.
Myelin basic protein (MBP) is an 18.5kDa protein encoded by the gene mapped to human chromosome 18q22qter. MBP is a major component of the myelin sheath and is highly expressed in central nervous system (CNS).

Immunogen

synthetic peptide corresponding to residues 102-116 of human Myelin Basic Protein.

Anwendung

Anti-Myelin Basic Protein (MBP) antibody produced in rabbit has been used in:
  • indirect immunolabeling
  • immunohistochemistry.
  • Western Blotting.
Anti-myelin basic protein (MBP) antibody (diluted 1:200) can be used as a primary antibody in double fluorescence labeling. It can also be used to detect myelin basic protein using immunoblotting.

Biochem./physiol. Wirkung

Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP functions as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzyme.

Physikalische Form

solution in phosphate buffered saline, containing 0.02% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

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Analysenzertifikate (COA)

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Functional motor recovery from motoneuron axotomy is compromised in mice with defective corticospinal projections.
Ding Y, et al.
PLoS ONE, 9 (2014)
C M Deber et al.
Clinical biochemistry, 24(2), 113-134 (1991-04-01)
Multiple sclerosis (MS) and a number of related distinctive diseases are characterized by the active degradation of central nervous system (CNS) myelin, an axonal sheath comprised essentially of proteins and lipids. These demyelinating diseases appear to arise from complex interactions
Neurotropin? Accelerates the Differentiation of Schwann Cells and Remyelination in a Rat Lysophosphatidylcholine-Induced Demyelination Model
Matsuoka H, et al.
International Journal of Molecular Sciences, 19 (2018)
MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis.
Vassall KA, et al.
The Biochemical Journal, 472, 17-32 (2015)
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