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Dokumente

J4649

Sigma-Aldrich

JNJ-10198409

≥98% (HPLC), solid

Synonym(e):

3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-Indeno[1,2-c]pyrazol-3-amine, RWJ 540973

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About This Item

Empirische Formel (Hill-System):
C18H16FN3O2
CAS-Nummer:
627518-40-5
Molekulargewicht:
325.34
UNSPSC-Code:
51111800
PubChem Substanz-ID:
329815736
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

solid

Farbe

off-white

Löslichkeit

DMSO: >10 mg/mL
H2O: <2 mg/mL

Ersteller

Johnson & Johnson

Lagertemp.

−20°C

SMILES String

COc1cc2Cc3c(Nc4cccc(F)c4)n[nH]c3-c2cc1OC

InChI

1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)

InChIKey

ZDNURMVOKAERHZ-UHFFFAOYSA-N

Biochem./physiol. Wirkung

JNJ-10198409 is a potent ATP-competitive inhibitor of Platelet-Derived Growth Factor receptor tyrosine kinase (PDGF-RTK) with both antiangiogenic and a direct tumor cell antiproliferative activity. It is selective for PDGF-β kinase with IC50 values of 4.2 nM for PDGF-β and 45 nM for PDGF-α kinase.

Leistungsmerkmale und Vorteile

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the PAF Receptor and PDGFR pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Chih Y Ho et al.
Journal of medicinal chemistry, 48(26), 8163-8173 (2005-12-22)
A series of (6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines has been optimized to preserve both potent kinase inhibition activity against the angiogenesis target, the receptor tyrosine kinase of Platelet-Derived Growth Factor-BB (PDGF-BB), and to improve the broad tumor cell antiproliferative activity of these compounds. This
Michael R D'Andrea et al.
Molecular cancer therapeutics, 4(8), 1198-1204 (2005-08-12)
With the advent of agents directed against specific molecular targets in drug discovery, it has become imperative to show a compound's cellular impact on the intended biomolecule in vivo. The objective of the present study was to determine if we

Artikel

PDGFR

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Discover Bioactive Small Molecules for Kinase Phosphatase Biology

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