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Y0000297

Mesalazin

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

5-Aminosalicylsäure, 5-AS, 5-Amino-2-hydroxy-benzoesäure, Mesalazin

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About This Item

Lineare Formel:
H2NC6H3-2-(OH)CO2H
CAS-Nummer:
89-57-6
Molekulargewicht:
153.14
Beilstein:
2090421
MDL-Nummer:
MFCD00007877
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329830901
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

mesalamine, mesalazine

Hersteller/Markenname

EDQM

mp (Schmelzpunkt)

275-280 °C (dec.) (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

Nc1ccc(O)c(c1)C(O)=O

InChI

1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)

InChIKey

KBOPZPXVLCULAV-UHFFFAOYSA-N

Angaben zum Gen

human ... ALOX5(240) , PPARG(5468) , PTGS1(5742) , PTGS2(5743)

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Verwandte Kategorien

Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

5-Aminosalicylsäure ist ein Peroxidasesubstrat, geeignet für den Einsatz in ELISA-Verfahren. Dieses Substrat bildet ein lösliches braunes Endprodukt, das spektralphotometrisch bei 450 nm ausgelesen werden kann. Die Reaktion kann mit 3 N NaOH gestoppt und bei 550 nm ausgelesen werden.

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

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Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Zielorgane

Respiratory system

WGK

WGK 2

Flammpunkt (°F)

No data available

Flammpunkt (°C)

No data available

Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

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Aminosalicylsäure United States Pharmacopeia (USP) Reference Standard

USP

1026401

Aminosalicylsäure

Mesalazin-Unreinheit C Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1739

Mesalazin-Unreinheit C

Sulfasalazin 97.0-101.5%

Sigma-Aldrich

S0883

Sulfasalazin

3-Amino-salicylsäure 97%

Sigma-Aldrich

255300

3-Amino-salicylsäure

4-Amino-salicylsäure 99%

Sigma-Aldrich

A79604

4-Amino-salicylsäure

Prednison ≥98%

Sigma-Aldrich

P6254

Prednison

Jeffrey B Raskin et al.
Gastroenterology, 147(4), 793-802 (2014-07-20)
No therapy has been proven to prevent the recurrence of diverticulitis. Mesalamine has shown efficacy in preventing relapse in inflammatory bowel disease, and there is preliminary evidence that it might be effective for diverticular disease. We investigated the efficacy of
David T Rubin et al.
Inflammatory bowel diseases, 14(2), 265-274 (2007-10-13)
A roundtable consensus meeting was held to consolidate current knowledge on the etiology of colorectal cancer in patients with inflammatory bowel disease and to review current strategies, both diagnostic and preventive, specifically addressing the role of 5-aminosalicylic acid. Specific topics
Max Karner et al.
The American journal of gastroenterology, 109(7), 1041-1051 (2014-05-07)
Phosphatidylcholine is a key component of the mucosal barrier. Treatment with modified release phosphatidylcholine aims to improve the impaired barrier function. The primary objective is to evaluate the efficacy of LT-02, a newly designed modified release phosphatidylcholine formula, in a
A M Schoepfer et al.
Alimentary pharmacology & therapeutics, 40(8), 930-937 (2014-08-26)
There is uncertain evidence of effectiveness of 5-aminosalicylates (5-ASA) to induce and maintain response and remission of active Crohn's disease (CD), and weak evidence to support their use in post-operative CD. To assess the frequency and determinants of 5-ASA use
A H Steinhart et al.
Alimentary pharmacology & therapeutics, 25(12), 1389-1399 (2007-06-02)
To evaluate the effectiveness of pH 6-/pH 7-dependent and controlled-release mesalazines in maintaining medically and surgically induced Crohn's disease remission. A systematic search identified 13 randomized controlled trials (RCTs). The rate of symptomatic relapse (Crohn's disease activity index >150, or
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