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PHR1384

Supelco

Amitriptylin-Hydrochlorid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

Amitriptylin -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C20H23N · HCl
CAS-Nummer:
549-18-8
Molekulargewicht:
313.86
EG-Nummer:
208-964-6
MDL-Nummer:
MFCD00012537
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329823361
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

300

Agentur

traceable to BP 16
traceable to Ph. Eur. Y0000563
traceable to USP 1029002

API-Familie

amitriptyline

Analysenzertifikat (CofA)

current certificate can be downloaded

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-30°C

SMILES String

Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

InChIKey

KFYRPLNVJVHZGT-UHFFFAOYSA-N

Angaben zum Gen

human ... SLC6A2(6530) , SLC6A4(6532)

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Verwandte Kategorien

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Amitriptyline hydrochloride is a drug, and a tricyclic antidepressant with anticholinergic activity. It is widely used in combination with chlordiazepoxide 7-chloro-2-(methyl-amino)-5-phenyl-3H-1,4-benzodiazepine-4-oxide for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety.

Anwendung

Amitriptyline hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and reversed-phase high-performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAA1640 in the slot below. This is an example certificate only and may not be the lot that you receive.

Ähnliches Produkt

Produkt-Nr.
Beschreibung
Preisangaben

1029002

Amitriptylin -hydrochlorid, United States Pharmacopeia (USP) Reference Standard

D1000000

Dibenzosuberon, European Pharmacopoeia (EP) Reference Standard

Y0000563

Amitriptylin -hydrochlorid, European Pharmacopoeia (EP) Reference Standard

1029013

Amitriptylin-verwandte Verbindung A, United States Pharmacopeia (USP) Reference Standard

1029024

Amitriptylin-verwandte Verbindung B, United States Pharmacopeia (USP) Reference Standard

PHR1776

5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ol, Pharmaceutical Secondary Standard; Certified Reference Material

BP016

Amitriptylin -hydrochlorid, British Pharmacopoeia (BP) Reference Standard

BP858

Dibenzosuberon, British Pharmacopoeia (BP) Reference Standard

PHR2836

Amitriptyline Related Compound A, certified reference material, pharmaceutical secondary standard

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2

Lagerklassenschlüssel

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number
LRAC4218
LRAD4680
LRAA9172
LRAA1640

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Simultaneous spectrophotometric determination of amitriptyline hydrochloride and chlordiazepoxide in pharmaceutical tablets by multivariate calibration method
Sarrafi MHA, et al.
Journal of Chemistry, 6(S1), S111-S116 (2009)
Spectrophotometric and chromatographic simultaneous estimation of amitriptyline hydrochloride and chlordiazepoxide in tablet dosage forms
Patel S, et al.
Indian Journal of Pharmaceutical Sciences, 71(4), 472-472 (2009)
Ming Yang et al.
Aquatic toxicology (Amsterdam, Netherlands), 151, 68-76 (2014-01-23)
Amitriptyline is a tricyclic antidepressant used for decades. It is present at low detectable concentrations in the aquatic environment, but relative few studies have focused on its ecotoxicological effects on non-target aquatic animals. The present study conducted an acute toxicity
Katja Kovacic et al.
The Journal of pediatrics, 164(5), 1104-1109 (2014-03-13)
To compare children with primary, chronic idiopathic nausea to those with secondary nausea associated with functional abdominal pain. Retrospective chart review of 45 children with a primary complaint of chronic nausea several times per week. Comparisons were made to prospectively
Mariola Herbet et al.
Acta poloniae pharmaceutica, 70(5), 913-917 (2013-10-24)
The aim of the present study was to assess the impact of combined therapy with rosuvastatin (10 mg/kg) and amitriptyline (10 mg/kg) on oxidation-reduction status in the blood of rats. After 2-week application of drugs alone or their combination, the
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