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SML0935

Sigma-Aldrich

Aripiprazol

≥98% (HPLC)

Synonym(e):

7-{4-[4-(2,3-Dichlorphenyl)-1-piperazinyl]-butoxy}-3,4-dihydro-2(1H)-chinolinon

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About This Item

Empirische Formel (Hill-System):
C23H27Cl2N3O2
CAS-Nummer:
129722-12-9
Molekulargewicht:
448.39
UNSPSC-Code:
12352200
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: 5 mg/mL, clear (warmed)

Lagertemp.

−20°C

InChI

1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)

InChIKey

CEUORZQYGODEFX-UHFFFAOYSA-N

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Allgemeine Beschreibung

3, 4 dihydro-2--(1H)quinolinone is the major component of aripiprazole.

Anwendung

Aripiprazole has been used to study behavioral and neurochemical effects of aripiprazole treatment in juvenile spontaneously hypertensive rats (SHR), a model for attention deficit hyperactivity disorder (ADHD).
Aripiprazole has been used to study its effect on mammary tumorigenesis, mediated by retrovirus delivery of receptor tyrosine-protein kinase 2 or HRas proto-oncogene, GTPase or by transgenic expression of Wnt-1 (proto-oncoprotein). It has also been used to study its behavioral and neurochemical effects in juvenile spontaneously hypertensive rats.

Biochem./physiol. Wirkung

Aripiprazole is a second generation atypical antipsychotic and anti-depressant with partial agonist activity at dopamine D2 and serotonin 5-HT1A receptors and antagonist activity at serotonin 5-HT2A receptors. Ki values are 0.34 nM, 0.8 nM, 1.7 nM, and 3.4 nM, respectively, for dopamine D2 and D3, serotonin 5-HT1A and 5-HT2A receptors. Aripiprazole is used in the treatment of schizophrenia.
Aripiprazole serves as a ‘dopaminergic stabilizer′. It is used as a potential therapeutic to treat schizophrenia patients. In addition, it is also preferably used to treat attention deficit hyperactivity disorder (ADHD) in patients with Tourette syndrome (TS).

Leistungsmerkmale und Vorteile

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Amisulprid ≥98% (HPLC)

Sigma-Aldrich

A2729

Amisulprid

Asenapine maleate ≥98% (HPLC)

Sigma-Aldrich

A7861

Asenapine maleate

Loxiglumide ≥97% (HPLC)

Sigma-Aldrich

SML0130

Loxiglumide

USP

USP

1042690

Aripiprazol-verwandte Verbindung G

Blonanserin ≥98% (HPLC)

Sigma-Aldrich

B7188

Blonanserin

Clozapin

Sigma-Aldrich

C6305

Clozapin

Dehydro aripiprazole solution 1.0 mg/mL in methanol with 5% 1 M HCl, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

D-053

Dehydro aripiprazole solution

Paliperidon ≥98% (HPLC)

Sigma-Aldrich

P0099

Paliperidon

D M Taylor
International journal of clinical practice, 57(1), 49-54 (2003-02-18)
Atypical antipsychotics generally have a lower propensity for extrapyramidal side-effects (EPSE), hyperprolactinaemia and tardive dyskinesia than that associated with typical antipsychotics but may still produce troublesome side-effects, such as weight gain, cardiac rhythm changes and impaired glucose tolerance. Aripiprazole is
Aripiprazole, a novel antipsychotic agent: dopamine D2 receptor partial agonist.
Hirose T and Kikuchi T
The Journal of Medical Investigation, 52(Supplement), 284-290 (2005)
Neil M Richtand et al.
Physiology & behavior, 106(2), 171-177 (2012-02-22)
Studies characterizing treatment interventions in a naturalistic setting suggest that antidepressant and antipsychotic medications may be equally effective in improving clinical outcome in individuals at high risk for first-episode psychosis. Of interest, both beneficial as well as potentially adverse effects
Aripiprazole and Riluzole treatment alters behavior and neurometabolites in young ADHD rats: a longitudinal 1 H-NMR spectroscopy study at 11.7 T.
Rizzo F, et al.
Translational Psychiatry, 7(8), e1189-e1189 null
Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions.
Johnston A N, et al.
Breast Cancer Research, 20(1), 42-42 (2018)
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