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Supelco

Tamoxifen

analytical standard

Synonym(e):

(Z)-1-(p-Dimethylaminethoxyphenyl)-1,2-diphenyl-1-buten, trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamin

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About This Item

Lineare Formel:
C6H5C(C2H5)=C(C6H5)C6H4OCH2CH2N(CH3)2
CAS-Nummer:
10540-29-1
Molekulargewicht:
371.51
EG-Nummer:
234-118-0
MDL-Nummer:
MFCD00010454
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329769367
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

100

Assay

≥98.0% (HPLC)

Haltbarkeit

limited shelf life, expiry date on the label

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Verunreinigungen

≤0.5% water

mp (Schmelzpunkt)

97-98 °C (lit.)

Anwendung(en)

forensics and toxicology
pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

CC\C(c1ccccc1)=C(/c2ccccc2)c3ccc(OCCN(C)C)cc3

InChI

1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-

InChIKey

NKANXQFJJICGDU-QPLCGJKRSA-N

Angaben zum Gen

human ... ESR1(2099)

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Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem./physiol. Wirkung

Proteinkinase C-Inhibitor. Induziert Apoptose in menschlichen malignen Gliomzelllinien. Tamoxifen und sein Metabolit 4-Hydroxytamoxifen sind selektive Östrogenrezeptormodulatoren (SERM), die als Östrogen-Antagonisten in Brustdrüsen wirken. Hemmt die Estradiol-stimulierte VEGF-Produktion in Brustkrebszellen.

Piktogramme

Health hazardEnvironment
GHS08,GHS09

Signalwort

Danger

Gefahreneinstufungen

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Repr. 1B

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

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Slide 1 of 6

1 of 6

4-Hydroxytamoxifen analytical standard, (E) and (Z) isomers (50:50)

Supelco

T176

4-Hydroxytamoxifen

(E/Z)-Endoxifen Hydrochloridhydrat ≥98% (HPLC)

Sigma-Aldrich

E8284

(E/Z)-Endoxifen Hydrochloridhydrat

4-Hydroxytamoxifen (E) and (Z) isomers (50:50), analytical standard

Supelco

94873

4-Hydroxytamoxifen

Tamoxifen-15N-(N,N-dimethyl-13C2) 99 atom % 13C, 99 atom % 15N, 99% (CP)

Sigma-Aldrich

608645

Tamoxifen-15N-(N,N-dimethyl-13C2)

Melatonin A hormone that has been postulated as the mediator of photo-induced anti-gonadotropic activity in photoperiodic mammals.

Sigma-Aldrich

444300

Melatonin

≥98% (HPLC)

Sigma-Aldrich

SML2368

(Z)-Endoxifen

Jack Cuzick et al.
The Lancet. Oncology, 16(1), 67-75 (2014-12-17)
Four previously published randomised clinical trials have shown that tamoxifen can reduce the risk of breast cancer in healthy women at increased risk of breast cancer in the first 10 years of follow-up. We report the long-term follow-up of the
L Binkhorst et al.
Clinical pharmacology and therapeutics, 92(4), 431-433 (2012-08-23)
Traditionally, all patients treated with tamoxifen receive a standard dose. A number of studies claimed a clinically relevant impact of cytochrome P450 2D6 (CYP2D6) genotype on outcome, and therefore genotyping before tamoxifen therapy was advocated. Recent data showed that adequate
Takeo Nakaya et al.
Cancer research, 74(10), 2882-2891 (2014-03-15)
The intestinal epithelium maintains homeostasis by a self-renewal process involving resident stem cells, including Lgr5(+) crypt-base columnar cells, but core mechanisms and their contributions to intestinal cancer are not fully defined. In this study, we examined a hypothesized role for
Karin Beelen et al.
Breast cancer research : BCR, 16(1), R13-R13 (2014-01-29)
Inhibitors of the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway can overcome endocrine resistance in estrogen receptor (ER) α-positive breast cancer, but companion diagnostics indicating PI3K/AKT/mTOR activation and consequently endocrine resistance are lacking. PIK3CA mutations frequently occur in ERα-positive
Wataru Ise et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(32), 11792-11797 (2014-07-30)
In primary humoral responses, B-cell lymphoma 6 (Bcl6) is a master regulator of follicular helper T (TFH) cell differentiation; however, its activation mechanisms and role in memory responses remain unclear. Here we demonstrate that survival of CXCR5(+) TFH memory cells
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