Direkt zum Inhalt
Merck
Alle Fotos(1)

Dokumente

16-246

Sigma-Aldrich

Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor™ 488

clone LA1, Upstate®, from mouse

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Konjugat

ALEXA FLUOR™ 488

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

LA1, monoclonal

Speziesreaktivität

human, mouse, rat

Hersteller/Markenname

Upstate®

Methode(n)

immunofluorescence: suitable

Isotyp

IgG1

NCBI-Hinterlegungsnummer

NM_005228.3
NM_201282.1
NM_201283.1
NM_201284.1

UniProt-Hinterlegungsnummer

P00533

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... EGFR(1956)
mouse ... Egfr(13649)
rat ... Egf(25313)

Allgemeine Beschreibung

Included Negative Control: Catalog # 16-240, Alexa Fluor™ 488-conjugated Normal Mouse IgG.

Inhibits A431 cell growth. Recognizes an antigenic determinant located on the extracellular domain of the receptor.

Spezifität

external domain of EGF receptor on all human cells. Competes with EGF and TGF-α for binding on human cells. Recognizes both phosphorylated and non-phosphorylated human EGF receptors.

Immunogen

Human A431 membrane proteins

Anwendung

Research Category
Zelluläre Signaltransduktion
Research Sub Category
Wachstumsfaktoren & -rezeptoren
This Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor 488 is validated for use in IF for the detection of EGFR.

Qualität

Routinely evaluated by positive immunostaining for the EGF receptor in A431 cells.

Lagerung und Haltbarkeit

1 year at 4°C from date of shipment

Rechtliche Hinweise

ALEXA FLUOR is a trademark of Life Technologies
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Alexa Fluor™ is a registered trademark of Molecular Probes, Inc.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Produkt-Auswahlhilfe.

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Matthew J Crow et al.
AJR. American journal of roentgenology, 192(4), 1021-1028 (2009-03-24)
The goal of this study was to assess whether immunolabeled nanoparticle biomarkers are comparable to fluorescent marker imaging in measuring epidermal growth factor receptor (EGFR) expression. EGFR expression was quantified using both imaging methods in four cell lines: A431 human
Cetuximab.
Goldberg, Richard M
Nature Reviews. Drug Discovery, Suppl, S10-S11 (2005)
Structure and function of the epidermal growth factor (EGF/ErbB) family of receptors.
Leahy, Daniel J
Advances in Protein Chemistry, 68, 1-27 (2004)
Epidermal growth factor inhibition in solid tumours.
Ganti, Apar Kishor and Potti, Anil
Expert opinion on biological therapy, 5, 1165-1174 (2005)
Intrinsic and acquired resistance to EGFR inhibitors in human cancer therapy.
Bianco, Roberto, et al.
Endocrine-Related Cancer, 12 Suppl 1, S159-S171 (2005)

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.