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Merck

D-061

Supelco

11-Deoxycortisol solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirische Formel (Hill-System):
C21H30O4
CAS-Nummer:
Molekulargewicht:
346.46
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

certified reference material

Qualitätsniveau

Form

liquid

Leistungsmerkmale

Snap-N-Spike®/Snap-N-Shoot®

Verpackung

ampule of 1 mL

Hersteller/Markenname

Cerilliant®

Konzentration

1.0 mg/mL in methanol

Methode(n)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Anwendung(en)

clinical testing
clinical testing

Format

single component solution

Lagertemp.

−20°C

SMILES String

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@@]4(C)[C@H]3CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1

InChIKey

WHBHBVVOGNECLV-OBQKJFGGSA-N

Allgemeine Beschreibung

A new calibration material suitable for multiple LC/MS applications in clinical and diagnostic testing and endocrinology. An immediate precursor to cortisol, 11-deoxycortisol, or cortodoxone, is measured in whole blood by LC-MS/MS for newborn screening of congenital adrenal hyperplasia (CAH) and in serum or plasma by LC-MS/MS for determination of several diseases including Cushing′s syndrome, pituitary tumor, and Addison′s disease.

Anwendung


  • Structural Analysis of Hyaluronan: The study used a mixed solvent system including 1,4-dioxane for the structural analysis of hyaluronan oligosaccharides, forming double-helical duplexes. This research is significant for pharmaceutical applications, particularly in drug delivery systems and regenerative medicine, demonstrating the solvent′s role in facilitating biochemical interactions (Kolaříková et al., 2024).

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

WGK

WGK 1

Flammpunkt (°F)

49.5 °F

Flammpunkt (°C)

9.7 °C


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Gwen E Dressing et al.
Endocrinology, 151(12), 5916-5926 (2010-10-22)
Although there is substantial evidence that membrane progestin receptors (mPRs) perform a critical physiological role in meiotic maturation of fish oocytes, it is unknown whether they are also intermediaries in progestin signaling in the surrounding follicular cells. Here, we show
Michael E Baker et al.
Steroids, 76(13), 1451-1457 (2011-08-16)
The serum of Atlantic sea lamprey, a basal vertebrate, contains two corticosteroids, 11-deoxycortisol and deoxycorticosterone. Only 11-deoxycortisol has high affinity [K(d) ~ 3 nM] for the corticoid receptor [CR] in lamprey gill cytosol. To investigate the binding of 11-deoxycortisol to
Jacqueline Jonklaas et al.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 18(1), 66-75 (2011-08-23)
To determine whether the time of day at which corticotropin stimulation testing is performed influences the steroid concentrations observed in persons with normal adrenal function. In this retrospective, secondary analysis, participants with normal adrenal function were studied to determine whether
Brett C McWhinney et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(28), 2863-2869 (2010-09-21)
We describe an ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC MS/MS) method suitable for a routine laboratory to determine endogenous and exogenous glucocorticoids in plasma, plasma ultrafiltrate, urine and saliva in a single analytical run. After addition of a
Lamprey endocrinology is not ancestral.
Joseph W Thornton et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(2), E5-E5 (2011-01-07)

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