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1508901

USP

Pentoxifylline

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

3,7-Dimethyl-1-(5-oxohexyl)xanthine, Trental

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About This Item

Empirical Formula (Hill Notation):
C13H18N4O3
CAS Number:
6493-05-6
Molecular Weight:
278.31
MDL number:
MFCD00063379
UNSPSC Code:
41116107
PubChem Substance ID:
329750705
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

pentoxifylline

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C

InChI

1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3

InChI key

MQGNNJQTNFHNHK-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Pentoxifylline USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Biochem/physiol Actions

Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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GHS07

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Warning

Hazard Classifications

Acute Tox. 4 Oral - Lact.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Shirinsadat Badri et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 14(1), 128-137 (2011-04-20)
Chronic kidney disease (CKD) as a considerable health problem may have proteinuria as the main complication and strong risk factor to reach end-stage renal disease (ESRD). Decreasing proteinuria is the mainstay of therapy in order to delay the progression of
R Parker et al.
Alimentary pharmacology & therapeutics, 37(9), 845-854 (2013-03-16)
Acute alcoholic hepatitis (AH) is a severe manifestation of alcoholic liver disease with a grave prognosis. Pentoxifylline, an oral antitumour necrosis factor agent, has been reported to reduce mortality and incidence of hepatorenal syndrome (HRS) in severe alcoholic hepatitis (SAH).
Simone Appenzeller et al.
Rheumatology international, 31(11), 1511-1513 (2009-12-17)
Behcet's disease is an inflammatory disorder of unknown cause, characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. All these common manifestations are self-limiting except for the ocular attacks. The objective of the present study is to
Emma Harris et al.
Paediatric drugs, 12(5), 301-311 (2010-08-31)
Sepsis, necrotizing enterocolitis (NEC), and chronic lung disease (CLD) in preterm neonates are associated with significant mortality and morbidity, including long-term neurodevelopmental impairment and socioeconomic burden. Safe and effective drugs for the prevention and treatment of these conditions are urgently
Khalid N Haque et al.
The Cochrane database of systematic reviews, (10)(10), CD004205-CD004205 (2011-10-07)
Mortality and morbidity due to neonatal sepsis and necrotizing enterocolitis (NEC) is high despite the use of potent antimicrobial agents. Agents that modulate inflammation may improve outcomes. Pentoxifylline, a phosphodiesterase inhibitor, is one such agent. The primary objectives were to
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