1414025
USP
Methotrexate Related Compound B
United States Pharmacopeia (USP) Reference Standard
Synonym(s):
Aminopterin, (S)-2-{4-[(2,4-Diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid, 4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid
About This Item
Recommended Products
grade
pharmaceutical primary standard
API family
methotrexate
manufacturer/tradename
USP
ε (extinction coefficient)
24,500 at 282 nm in 0.1 M NaOH at 1 M
25,700 at 261 nm in 0.1 M NaOH at 1 M
8,100 at 373 nm in 0.1 M NaOH at 1 M
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1
InChI
1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1
InChI key
TVZGACDUOSZQKY-LBPRGKRZSA-N
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General description
For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Additionally used to prepare standard, standard stock, system suitability, and system suitability stock solutions for impurity analysis in the given below monographs according to United States Pharmacopeia (USP):
- Methotrexate
- Methotrexate Injection
- Methotrexate for Injection
Biochem/physiol Actions
Linkage
Analysis Note
Other Notes
related product
signalword
Danger
Hazard Classifications
Acute Tox. 1 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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