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1005706

USP

Glacial acetic acid

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Acetic acid, Ethanoic acid, Methanecarboxylic acid, Glacial acetic acid

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About This Item

Linear Formula:
CH3CO2H
CAS Number:
64-19-7
Molecular Weight:
60.05
Beilstein/REAXYS Number:
506007
MDL number:
MFCD00036152
UNSPSC Code:
41116107
PubChem Substance ID:
329748133
NACRES:
NA.24

grade

pharmaceutical primary standard

vapor density

2.07 (vs air)

API family

glacial acetic acid

autoignition temp.

800 °F

expl. lim.

16 %, 92 °F
4 %, 59 °F

manufacturer/tradename

USP

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.371 (lit.)

bp

117-118 °C (lit.)

mp

16.2 °C (lit.)

density

1.04 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC(O)=O

InChI

1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)

InChI key

QTBSBXVTEAMEQO-UHFFFAOYSA-N

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General description

Glacial acetic acid is the trivial name used to describe pure acetic acid in an anhydrous state. It is a clear and hygroscopic weak acid, typically available in concentrations ranging from 99.5% to 100%. The name "glacial" refers to the ice-like crystals that form at a temperature slightly below room temperature (16.6°C or 61.9°F), like the German term "Eisessig" (ice-vinegar). Despite being classified as a weak acid, glacial acetic acid is a corrosive poison that can cause harm or even be fatal when in contact with human tissue. Improper storage and handling of glacial acetic acid can pose inherent risks and may lead to patient injuries if not appropriately diluted. Acetic acid/acetate is a common counter ion in peptide preparations.
Glacial acetic acid USP reference standard is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Glacial acetic acid USP reference standard for use in specified quality tests and assays. It is also used to prepare standard solution by using liquid chromatography coupled to a UV detector according to the general chapter of United States Pharmacopeia (USP). Based directly on official monographs published in the USP-NF, these highly characterized physical specimens are used in testing by pharmaceutical and related industries to help ensure the identity, strength, quality, and purity of peptide-based medicines.

Further information is available in the general chapter, 503- ACETIC ACID IN PEPTIDES, USP43-NF38 - 6741 of the USP (United States Pharmacopeia).

Other Notes

This product is part of the USP Biologics program.
Sales restrictions may apply.

related product

Product No.
Description
Pricing

pictograms

FlameCorrosion
GHS02,GHS05

signalword

Danger

hcodes

H226,H314

Hazard Classifications

Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A

wgk_germany

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Isoamyl acetate ≥95%, FCC, FG

Sigma-Aldrich

W205508

Isoamyl acetate

Acetic acid glacial, ≥99.99% trace metals basis

Sigma-Aldrich

338826

Acetic acid

Sodium hypochlorite solution reagent grade, available chlorine 10-15 %

Sigma-Aldrich

425044

Sodium hypochlorite solution

Acetic Acid, Glacial Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs GR ACS

Supelco

AX0073

Acetic Acid, Glacial

Acetic acid glacial, ACS reagent, ≥99.7%

Sigma-Aldrich

695092

Acetic acid

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