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T5699

Sigma-Aldrich

m-3M3FBS

>97% (HPLC)

Synonym(s):

2,4,6-Trimethyl-N-(3-trifluoromethyl-phenyl)-benzenesulfonamide, N-(3-Trifluoromethylphenyl)-2,4,6-trimethylbenzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C16H16F3NO2S
CAS Number:
200933-14-8
Molecular Weight:
343.36
MDL number:
MFCD00095824
UNSPSC Code:
41106300
PubChem Substance ID:
329826829
NACRES:
NA.77

assay

>97% (HPLC)

form

powder

color

white

mp

114-114.8 °C (lit.)

solubility

DMSO: >20 mg/mL

SMILES string

Cc1cc(C)c(c(C)c1)S(=O)(=O)Nc2cccc(c2)C(F)(F)F

InChI

1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3

InChI key

ZIIUUSVHCHPIQD-UHFFFAOYSA-N

Application

m-3M3FBS has been used for MAP kinase assay in 293T cells. It has also been used for intracellular calcium analysis1. Furthermore, it has been used (at a conc. of 1 μM) as a PLC activator for sensitizing TRPA1 in HEK293t cells2.

Biochem/physiol Actions

First known direct activator of phospholipase C (activates β2, β3, γ1, γ2, δ1 isoforms).

Preparation Note

m-3M3FBS is soluble in DMSO at a concentration that is greater than 20 mg/ml.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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