SML3553
STF-1084
≥98% (HPLC)
Synonym(s):
ENPP1 inhibitor Compound 15, P-[2-[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]ethyl]-phosphonic acid
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About This Item
Empirical Formula (Hill Notation):
C17H24N3O5P
CAS Number:
Molecular Weight:
381.36
UNSPSC Code:
12352200
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=P(O)(O)CCC(CC1)CCN1C2=NC=NC3=C2C=C(OC)C(OC)=C3
Biochem/physiol Actions
STF-1084 (ENPP1 inhibitor Compound 15) Is a cell-impermeable, potent, selective, stable and nontoxic competitive inhibitor of ENPP1 (ectonucleotide pyrophosphatase phosphodiesterase 1) that inhibit degradation of extracellular cGAMP under physiological conditions. STF-1084 had no effect on intracellular cGAMP. STF-1084 synergized with IR to significantly delay tumor progression in three triple-negative breast cancer cell lines 4T1-luc mice model.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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