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SAB5700522

Sigma-Aldrich

Anti-Phospho-STAT5-Y694 antibody produced in rabbit

Synonym(s):

MGF, STAT5, stat5a/stat5b

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

90

species reactivity

human, rat, mouse

concentration

2.75 mg/ml

technique(s)

immunohistochemistry: 1:100-1:200
western blot: 1:500-1:2000

UniProt accession no.

P42229
P51692

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr694)

Gene Information

human ... STAT5(6776)

Related Categories

General description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.

Immunogen

A phospho specific peptide corresponding to residues surrounding Y694 of human STAT5.

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

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wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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