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SAB4503834

Sigma-Aldrich

Anti-phospho-SGK (pSer422) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 48 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

O00141

UniProt accession no.

O00141

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer422)

Gene Information

human ... SGK1(6446)

General description

The serum- and glucocorticoid-regulated kinase (Sgk1) is a member of the AGC kinase family. It is located on human chromosome 6q23.

Immunogen

The antiserum was produced against synthesized peptide derived from human SGK around the phosphorylation site of Ser422.

Immunogen Range: 381-430

Biochem/physiol Actions

The serum- and glucocorticoid-regulated kinase (Sgk1) controls ENaC (expressed renal epithelial Na+ channel) by mineralocorticoids. SGK1 controls p27 phosphorylation upon the activation by mTOR-Raptor.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Saniya Ossikbayeva et al.
Antioxidants (Basel, Switzerland), 10(10) (2021-10-24)
Anticancer activities of plant polyphenols have been demonstrated in various models of neoplasia. However, evidence obtained in numerous in vitro studies indicates that proliferation arrest and/or killing of cancer cells require quite high micromolar concentrations of polyphenols that are difficult
Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables
Ellison DW, et al.
Journal of Clinical Oncology, 29(11), 1400-1407 (2011)
mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation
Hong F, et al.
Molecular Cell, 30(6), 701-711 (2008)
Impaired renal Na(+) retention in the sgk1-knockout mouse
Wulff P, et al.
The Journal of Clinical Investigation, 110(9), 1263-1268 (2002)
Bidisha Saha et al.
Journal of cell science, 135(23) (2022-11-15)
Mammalian (or mechanistic) target of rapamycin complex 2 (mTORC2) is a kinase complex that targets predominantly Akt family proteins, SGK1 and protein kinase C (PKC), and has well-characterized roles in mediating hormone and growth factor effects on a wide array
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