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RES10070-A7

SAFC

L-Asparagine monohydrate

Pharma Manufacturing

Synonym(s):

(S)-(+)-2-Aminosuccinamic acid, (S)-2-Aminosuccinic acid 4-amide, L-Aspartic acid 4-amide

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About This Item

Linear Formula:
NH2COCH2CH(NH2)COOH · H2O
CAS Number:
5794-13-8
Molecular Weight:
150.13
Beilstein/REAXYS Number:
1723527
EC Number:
200-735-9
MDL number:
MFCD00151038
UNSPSC Code:
12352209
NACRES:
NA.21

biological source

synthetic

Quality Level

400

assay

98.5-101.0% dry basis

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin and microbial, tested

mp

233-235 °C (lit.)

suitability

suitable for manufacturing use

foreign activity

Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

SMILES string

[H]O[H].N[C@@H](CC(N)=O)C(O)=O

InChI

1S/C4H8N2O3.H2O/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H2,6,7)(H,8,9);1H2/t2-;/m0./s1

InChI key

RBMGJIZCEWRQES-DKWTVANSSA-N

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General description

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Application

L-Asparagine is an essential amino acid. It is used as a cell culture media component and raw material for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

Packaging

Product is available in the following package sizes:
RES10070-A701X: 100g container
RES10070-A702X: 1kg container
RES10070-A704X: 10kg container

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Product No.
Description
Pricing

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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L-Asparagine ≥98% (HPLC)

Sigma-Aldrich

A0884

L-Asparagine

Asparagine anhydrous United States Pharmacopeia (USP) Reference Standard

USP

1043502

Asparagine anhydrous

L-Aspartic acid

SAFC

A5474

L-Aspartic acid

D-Asparagine monohydrate ≥99% (TLC)

Sigma-Aldrich

A8131

D-Asparagine monohydrate

L-Cystine dihydrochloride, non-animal derived

SAFC

RES1513C-A7

L-Cystine dihydrochloride, non-animal derived

Deia Abd El-Hady et al.
Food chemistry, 188, 551-558 (2015-06-05)
Acrylamide (AA) is a known lethal neurotoxin and carcinogen. AA is formed in foods during the browning process by the Maillard reaction of glucose (GL) with asparagine (AS). For the first time, the simultaneous online preconcentration and separation of AA
Gustavo Luis Leonardo Scalone et al.
Journal of agricultural and food chemistry, 63(22), 5364-5372 (2015-05-15)
Pyrazines are specific Maillard reaction compounds known to contribute to the unique aroma of many products. Most studies concerning the generation of pyrazines in the Maillard reaction have focused on amino acids, while little information is available on the impact
Han Yao et al.
Journal of pharmaceutical and biomedical analysis, 117, 232-239 (2015-09-18)
L-asparaginase is an effective anti-tumor agent for acute lymphoblastic leukemia. This work presents the development of an activity determination of L-ASNase preparations for pharmaceutical quality control purposes, in accordance with analytical Quality by Design principles. Critical method attributes, the absorbance

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