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Q0875

Sigma-Aldrich

Quinidine sulfate salt dihydrate

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About This Item

Empirical Formula (Hill Notation):
C40H48N4O4 · H2O4S · 2H2O
CAS Number:
6591-63-5
Molecular Weight:
782.94
EC Number:
200-046-3
MDL number:
MFCD00149346
UNSPSC Code:
12352200
PubChem Substance ID:
24277870
NACRES:
NA.77

Quality Level

200

impurities

≤20% Dihydroquinidine (according to USP specifications., actual content given on label)

mp

212-214 °C (dec.) (lit.)

originator

Bayer

SMILES string

[H]O[H].[H]O[H].OS(O)(=O)=O.[H][C@]1(CN2CCC1C[C@]2([H])[C@@H](O)c3ccnc4ccc(OC)cc34)C=C.[H][C@]5(CN6CCC5C[C@]6([H])[C@@H](O)c7ccnc8ccc(OC)cc78)C=C

InChI

1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m11.../s1

InChI key

ZHNFLHYOFXQIOW-WFTMRWCJSA-N

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General description

Quinidine is an alkaloid present in the bark of the Cinchona tree. It is the D-isomer of quinine, an antimalarial drug.

Application

Quinidine sulfate salt dihydrate has been used as an antiarrhythmic drug to study its effects on phosphorylation and mutations in the cardiac sodium channel Nav1.5.

Biochem/physiol Actions

Quinidine shows therapeutic effects against atrial fibrillation and cardiac arrhythmias.
Class IA antiarrhythmic; potassium channel blocker.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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