Skip to Content
MilliporeSigma
All Photos(1)

Documents

P6273

Sigma-Aldrich

2-Propylpentanoic acid

Synonym(s):

Valproic acid

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
(CH3CH2CH2)2CHCO2H
CAS Number:
99-66-1
Molecular Weight:
144.21
EC Number:
202-777-3
MDL number:
MFCD00002672
UNSPSC Code:
12352211
PubChem Substance ID:
24898751
NACRES:
NA.25

Quality Level

200

refractive index

n20/D 1.425 (lit.)

bp

220 °C (lit.)

solubility

H2O: slightly soluble
alcohol: soluble

density

0.9 g/mL at 25 °C (lit.)

lipid type

saturated FAs

SMILES string

CCCC(C(O)=O)CCC

InChI

1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)

InChI key

NIJJYAXOARWZEE-UHFFFAOYSA-N

Gene Information

human ... ALDH5A1(7915) , CYP1A2(1544)
mouse ... Hdac1(433759)
rat ... Slc6a1(79212)

Looking for similar products? Visit Product Comparison Guide

Application

2-Propylpentanoic acid has been used as a supplement in mouse embryonic fibroblast - conditioned medium (MEF-CM) to feed the cells.

Biochem/physiol Actions

2-Propylpentanoic acid is a short-chain fatty acid and potentially inhibits histone deacetylase action. It is known to promote tumor cell toxicity and increase susceptibility to radiation. 2-Propylpentanoic acid elevates the levels of γ-aminobutyric acid in the brain. Reduced central nervous system action is observed in overdosage of 2-propylpentanoic acid. It enhance the inhibitory action of γ-aminobutyric acid (GABA) by blocking voltage-dependent sodium channel.
Anticonvulsant that also has efficacy as a mood stabilizer in bipolar disorder

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2

wgk_germany

WGK 3

flash_point_f

closed cup

flash_point_c

closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 7

1 of 7

12-Methyltetradecanoic acid

Sigma-Aldrich

M3664

12-Methyltetradecanoic acid

14-Methylhexadecanoic acid

Sigma-Aldrich

M3164

14-Methylhexadecanoic acid

Sodium valproate British Pharmacopoeia (BP) Reference Standard

BP452

Sodium valproate

1&#160;mg/mL in methanol, ampule of 1&#160;mL, certified reference material, Cerilliant<SUP>&#174;</SUP>

Supelco

V-029

Valproic Acid-D6 solution

&#8805;98% (capillary GC)

Sigma-Aldrich

M6781

Isopalmitic acid

2-Hexyldecanoic acid 96%

Sigma-Aldrich

464449

2-Hexyldecanoic acid

(±)-3-Methyl-2-oxovaleric acid sodium salt

Sigma-Aldrich

K7125

(±)-3-Methyl-2-oxovaleric acid sodium salt

Bonan Zhong et al.
Stem cells and development, 20(5), 795-807 (2010-11-10)
Induced pluripotent stem (iPS) cells have great potential for regenerative medicine and gene therapy. Thus far, iPS cells have typically been generated using integrating viral vectors expressing various reprogramming transcription factors; nonintegrating methods have been less effective and efficient. Because
Histone deacetylase inhibitor, 2-propylpentanoic acid, increases the chemosensitivity and radiosensitivity of human glioma cell linesin vitro
Cuijie S, et al.
Chinese Medical Journal (English Edition), 125(24), 4338-4343 (2012)
Efficient generation of nonhuman primate induced pluripotent stem cells
Zhong B, et al.
Stem Cells and Development, 20(5), 795-807 (2010)
3-Heptanone as a potential new marker for valproic acid therapy
Erhart S, et al.
Journal of Breath Research, 3(1), 016004-016004 (2009)
Irma Virant-Klun et al.
Cells, 8(7) (2019-07-25)
A population of small stem cells with diameters of up to 5 μm resembling very small embryonic-like stem cells (VSELs) were sorted from human embryonic stem cell (hESC) cultures using magnetic-activated cell sorting (MACS) based on the expression of a
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service