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N7627

Sigma-Aldrich

L-Norvaline

≥99% (TLC)

Synonym(s):

(S)-(+)-2-Aminopentanoic acid, (S)-2-Aminovaleric acid

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About This Item

Linear Formula:
CH3CH2CH2CH(NH2)CO2H
CAS Number:
6600-40-4
Molecular Weight:
117.15
Beilstein/REAXYS Number:
1721162
EC Number:
229-543-3
MDL number:
MFCD00064421
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24897833
NACRES:
NA.26

product name

L-Norvaline, arginase inhibitor

Quality Level

200

assay

≥99% (TLC)

form

powder

color

white

mp

>300 °C (lit.)

application(s)

detection

SMILES string

CCC[C@H](N)C(O)=O

InChI

1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

InChI key

SNDPXSYFESPGGJ-BYPYZUCNSA-N

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Application


  • Nanodrugs mediate TAMs-related arginine metabolism interference to boost photodynamic immunotherapy.: This study explores the use of nanodrugs to interfere with arginine metabolism in tumor-associated macrophages (TAMs), enhancing the efficacy of photodynamic immunotherapy. L-Norvaline plays a crucial role in this metabolic interference (Chen et al., 2024).

Biochem/physiol Actions

L-Norvaline enhances NO production from activated macrophages.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sigma-Aldrich

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Sigma-Aldrich

S7672

Sarcosine

Sarcosine 98%

Sigma-Aldrich

131776

Sarcosine

L-Norvaline-1-13C 99 atom % 13C

Sigma-Aldrich

570117

L-Norvaline-1-13C

BEC, Hydrochloride A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5).

Sigma-Aldrich

197900

BEC, Hydrochloride

Ying-Chen Lin et al.
The New phytologist, 223(4), 1904-1917 (2019-05-16)
Choline kinase catalyzes the initial reaction step of choline metabolism that produces phosphocholine, a prerequisite for the biosynthesis of a primary phospholipid phosphatidylcholine. However, the primary choline kinase and its role in plant growth remained elusive in seed plants. Here
Seyed Abdollah Hosseini et al.
International journal of molecular sciences, 20(4) (2019-03-01)
The importance of magnesium (Mg) for plant growth is well-documented. Silicon (Si)-mediated alleviation of mineral deficiencies has been also reported in a number of plant species; however, there is no report on the relevance of Si nutrition in plants grown
Nelson Machado et al.
Journal of the science of food and agriculture, 97(13), 4295-4305 (2017-03-10)
Freezing represents a common conservation practice regarding vegetal foodstuffs. Since compositional features need to be monitored during storage, the development of rapid monitoring tools suitable for assessing nutritional characteristics arises as a pertinent issue. In this study, cowpea (Vigna unguiculata
C I Chang et al.
The American journal of physiology, 274(1 Pt 2), H342-H348 (1998-02-12)
In macrophages and many other cell types, L-arginine is used as a substrate by both nitric oxide synthase (NOS) and arginase to produce nitric oxide (NO) and urea, respectively. Because the availability of L-arginine is a major determinant for NO
W Sosroseno et al.
Oral microbiology and immunology, 21(3), 145-150 (2006-04-22)
The aim of the present study was to determine whether or not lipopolysaccharide from Actinobacillus actinomycetemcomitans could stimulate arginase activity in a murine macrophage cell line (RAW264.7 cells). RAW264.7 cells were treated with A. actinomycetemcomitans-lipopolysaccharide or lipopolysaccharide from Escherichia coli
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