Skip to Content
MilliporeSigma
All Photos(4)

Documents

M8750

Sigma-Aldrich

(+)-Methamphetamine hydrochloride

Synonym(s):

d-Desoxyephedrine hydrochloride, d-N,α-Dimethylphenethylamine hydrochloride, Methylamphetamine hydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(4)

About This Item

Empirical Formula (Hill Notation):
C10H15N · HCl
CAS Number:
51-57-0
Molecular Weight:
185.69
EC Number:
200-106-9
MDL number:
MFCD00056130
UNSPSC Code:
12352116
PubChem Substance ID:
24897282
NACRES:
NA.77

Quality Level

200

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

solubility

H2O: soluble
ethanol: soluble

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

originator

Teva

SMILES string

Cl[H].CN[C@@H](C)Cc1ccccc1

InChI

1S/C10H15N.ClH/c1-9(11-2)8-10-6-4-3-5-7-10;/h3-7,9,11H,8H2,1-2H3;1H/t9-;/m0./s1

InChI key

TWXDDNPPQUTEOV-FVGYRXGTSA-N

Gene Information

human ... SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Biochem/physiol Actions

Sympathomimetic with more potent central effects than amphetamine. It is transported into terminals via the monoamine transporters and induces release of dopamine, norepinephrine, epinephrine, and serotonin. Dopamine release is important for the addictive properties of methamphetamine while norepinephrine and epinephrine release are important for the cardiovascular effects. Serotonin neurotoxin.

Features and Benefits

This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300,H336

Hazard Classifications

Acute Tox. 2 Oral - STOT SE 3

target_organs

Central nervous system

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 2

1 of 2

(±)-Methamphetamine-D14 solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

M-093

(±)-Methamphetamine-D14 solution

Levmetamfetamine United States Pharmacopeia (USP) Reference Standard

USP

1359506

Levmetamfetamine

G J Rivière et al.
The Journal of pharmacology and experimental therapeutics, 291(3), 1220-1226 (1999-11-24)
The purpose of these studies was to better understand the behavioral effects and pharmacokinetics of an i.v. bolus dose of (+)-methamphetamine [(+)-METH] in a rat model of (+)-METH abuse. We characterized the behavioral effects after increasing (+)-METH doses (0.1, 0.3
Kaveh Shahveisi et al.
Pharmacology, biochemistry, and behavior, 185, 172759-172759 (2019-08-16)
Susceptibility to interference can be a result of memory retrieval and reconsolidation. Given the fact that addiction develops through the neural mechanisms of learning and memory, it would not be surprising that a consolidated drug reward memory may also be
Noémie Cresto et al.
International journal of molecular sciences, 22(13) (2021-07-03)
Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson's disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that are not yet fully understood. We previously showed that the
Shaolin Yang et al.
Addiction biology, 20(1), 69-79 (2013-08-06)
(1) H magnetic resonance spectroscopy has demonstrated alterations in several neurometabolites in methamphetamine (METH)-dependent individuals in brain regions implicated in addiction. Yet, it is unclear whether these neurochemicals return to homeostatic levels after an individual abstains from drug use, a
Betina González et al.
Neuropharmacology, 87, 188-197 (2014-02-18)
Chronic use of methamphetamine (METH) leads to long-lasting cognitive dysfunction in humans and in animal models. Modafinil is a wake-promoting compound approved for the treatment of sleeping disorders. It is also prescribed off label to treat METH dependence. In the
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service