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M3655

Sigma-Aldrich

D-Mannose 6-phosphate sodium salt

≥98% (HPLC)

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About This Item

Linear Formula:
C6H12O9PNa
CAS Number:
70442-25-0
Molecular Weight:
282.12
MDL number:
MFCD00135859
UNSPSC Code:
12352201
PubChem Substance ID:
24896863
NACRES:
NA.25

biological source

synthetic (inorganic)

Quality Level

200

assay

≥98% (HPLC)

form

powder

technique(s)

HPLC: suitable

impurities

<12% water (Karl Fischer)

color

white

solubility

water: 50 mg/mL, clear to cloudy, colorless

cation traces

Na: 7.3-9.0% (anhydrous)

storage temp.

2-8°C

SMILES string

[Na].OC(COP(O)(O)=O)C(O)C(O)C(O)C=O

InChI

1S/C6H13O9P.Na.H/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14;;/h1,3-6,8-11H,2H2,(H2,12,13,14);;

InChI key

RUFPTDNHMAGVMV-UHFFFAOYSA-N

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General description

Mannose is a monosaccharide.

Application

Mannose has been used in a study to assess in vivo targeting of alveolar macrophages. It has also been used in a study to investigate genetic engineering of the phosphocarrier protein NPr.

Biochem/physiol Actions

Mannose-6-Pis a molecule bound by lectin in the immune system. It is converted to fructose 6-phosphate by mannose phosphate isomerase and is a key targeting signal for acid hydrolase precursor proteins that are transported to lysosomes.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Yossef Lopez-de Los Santos et al.
The Journal of biological chemistry, 287(35), 29931-29939 (2012-07-07)
The Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system (PTS) in prokaryotes mediates the uptake and phosphorylation of its numerous substrates through a phosphoryl transfer chain where a phosphoryl transfer protein, HPr, transfers its phosphoryl group to any of several sugar-specific Enzyme IIA
Ningning Yang et al.
Journal of controlled release : official journal of the Controlled Release Society, 155(2), 326-330 (2011-07-19)
Triplex-forming oligonucleotides (TFOs) represent an antigene approach for gene regulation through direct interaction with genomic DNA. While this strategy holds great promise owing to the fact that only two alleles need silencing to impact gene regulation, delivering TFOs to target
Maria Francisca Coutinho et al.
Molecular genetics and metabolism, 105(4), 542-550 (2012-01-24)
Lysosomal hydrolases are synthesized in the rough endoplasmic reticulum and specifically transported through the Golgi apparatus to the trans-Golgi network, from which transport vesicles bud to deliver them to the endosomal/lysosomal compartment. The explanation of how are the lysosomal enzymes
Xuezheng Song et al.
Methods in molecular biology (Clifton, N.J.), 808, 137-148 (2011-11-08)
Glycan microarrays prepared by immobilization of amino-functionalized glycans on NHS-activated glass slides have been successfully used to study protein-glycan interactions. Fluorescently tagged glycans with an amino functional group can be prepared from natural glycans released from glycoproteins. These tagged glycans
Changsuo Xia et al.
Orthopedics, 35(7), e1056-e1060 (2012-07-13)
The purpose of this study was to investigate the preventive effect of mannose-6-phosphate on flexor tendon adhesion formation. From a total of 84 adult New Zealand White rabbits, 36 were randomly divided into 2 groups, the normal saline group and
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