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L090000

Sigma-Aldrich

Dichloromethane

Synonym(s):

Methylene chloride

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About This Item

Empirical Formula (Hill Notation):
CH2Cl2
CAS Number:
75-09-2
Molecular Weight:
84.93
Beilstein/REAXYS Number:
1730800
EC Number:
200-838-9
MDL number:
MFCD00000881
UNSPSC Code:
12352101
PubChem Substance ID:
329817376
NACRES:
NA.21

vapor density

2.9 (vs air)

Quality Level

200

vapor pressure

24.45 psi ( 55 °C)
6.83 psi ( 20 °C)

type

for DNA synthesis

product line

Proligo Reagents

form

liquid

autoignition temp.

1223 °F

contains

amylene as stabilizer

expl. lim.

22 %

storage condition

dry at room temperature

impurities

≤50 ppm water content (Karl Fischer)

color

clear

refractive index

n/D 1.421-1.425
n20/D 1.424 (lit.)

bp

39.8-40 °C (lit.)

mp

−95 °C (lit.)

density

1.325 g/mL at 25 °C (lit.)

SMILES string

ClCCl

InChI

1S/CH2Cl2/c2-1-3/h1H2

InChI key

YMWUJEATGCHHMB-UHFFFAOYSA-N

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General description

In the solid-phase synthesis of oligonucleotides, liquid reagents are used in each step of the synthesis cycle. Overall synthesis performance, and therefore total product yield and purity of the crude oligonucleotide, is highly dependent on the chemical purity of the monomers and the supporting liquid reagents and other solvents like ethylacetate, dichloromethane, and dimethylformadine .Dichloromethane is an ordinary organic solvent frequently utilized in peptide synthesis. Under normal circumstances, DCM maintains highly stable and will not cause significant side reactions in peptide synthesis. It is a chlorinated organic solvent that is susceptible to degradation with time. This can be suppressed by adding amylene as a stabilizer.Dichloromethane has been tested as a solvent medium for the dipyridine-chromium(VI) oxide. Solubility was reported to be 12.5g/100ml. The role of the quantity of TiO2 loading on activated carbon support employed in the photodecomposition of dichloromethane has been investigated.

Application

Dichloromethane may be used as a solvent for the preparation of stock solutions of carotenoids. It may be employed as a solvent in the synthesis of polylactide-based (PLA) thin films. IT is also suitable as a solvent for the oxidation of primary and secondary alcohols using dipyridine-chromium(VI) oxide.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Central nervous system

wgk_germany

WGK 2

flash_point_f

does not flash

flash_point_c

does not flash

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Dichloromethane ACS reagent, ≥99.5%, contains 40-150 ppm amylene as stabilizer

Sigma-Aldrich

676853

Dichloromethane

Khalef Lefsih et al.
Phytochemistry, 154, 47-55 (2018-07-15)
This work aims to fill the gap in the present knowledge about the structure of pectin from Opuntia ficus-indica. The water-soluble pectin (WSP) fraction, extracted with the Microwave Assisted Extraction (MAE), was further deproteinated (dWSP) and analyzed through several biophysical

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