H9291
Hemopexin from human plasma
≥95% (SDS-PAGE), lyophilized powder
Synonym(s):
HPX, HX, Hpxn, beta-1B-glycoprotein
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About This Item
CAS Number:
UNSPSC Code:
12352202
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General description
Hemopexin (HPX) is produced by cells of the central nervous system. It is a 60 kDa serum glycoprotein.
Application
Hemopexin from human plasma has been used S. aureus surface colonization assay. It has also been used to stimulate mixed lymphocyte cells to determine the biomarkers in acute rejection.
Biochem/physiol Actions
Hemopexin is an acute-phase protein that plays a major protective role against oxidative stress through its heme-scavenging activities. Hemopexin binds heme with high affinity and is critical for recycling the iron bound to heme molecules and for protecting against heme-induced cellular damage. Free heme, when released or lost from proteins like hemoglobin, can catalyze the formation of reactive oxygen species. Heme is lipophilic and interchelates into lipid membranes and participate in the formation of highly-toxic hydroxyl radicals. Hemopexin may also protect against the heme-mediated oxidation of LDL cholesterol.
Hemopexin may also serve an anti-inflammatory role via the negative regulation of IL-6 and TNF-α secretion by activated macrophages.
Hemopexin may also serve an anti-inflammatory role via the negative regulation of IL-6 and TNF-α secretion by activated macrophages.
Physical form
Lyophilized powder containing sodium phosphate, NaCl, and KCl, pH 7.4
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Francesca Vinchi et al.
Circulation, 127(12), 1317-1329 (2013-03-01)
Hemolytic diseases are characterized by enhanced intravascular hemolysis resulting in heme-catalyzed reactive oxygen species generation, which leads to endothelial dysfunction and oxidative damage. Hemopexin (Hx) is a plasma heme scavenger able to prevent endothelial damage and tissue congestion in a
Yu-Hong Shi et al.
Dong wu xue yan jiu = Zoological research, 33(5), 481-486 (2012-09-29)
The warm temperature acclimation related 65 kDa protein-2 (Wap65-2), a teleost plasma glycoprotein, plays an important role in immune regulation against bacterial infection. Here, for the first time we determined the full length cDNA sequence of the Japanese sea bass
Zhengyang Wang et al.
Biochimica et biophysica acta, 1824(4), 692-700 (2012-02-14)
The pleural effusion proteome has been found containing information that directly reflects pathophysiological status and represents a potential diagnostic value for pulmonary diseases. However, the variability in protein composition between malignant and benign effusions is not well understood. Herein, we
Paolo Ascenzi et al.
Biochemical and biophysical research communications, 428(2), 239-244 (2012-10-17)
Hemopexin (HPX) displays a pivotal role in heme scavenging and delivery to the liver. In turn, heme-Fe-hemopexin (HPX-heme-Fe) displays heme-based spectroscopic and reactivity properties. Here, kinetics and thermodynamics of cyanide binding to ferric and ferrous hexa-coordinate human plasma HPX-heme-Fe (HHPX-heme-Fe(III)
Tirthartha Chattopadhyay et al.
Biochemical and biophysical research communications, 420(4), 862-868 (2012-04-03)
Proteins containing hemopexin fold domain are suggested to have diverse functions in various living organisms. In order to investigate the structure and function of this type of protein in rice plant (Oryza sativa), the gene encoding a hemopexin fold protein
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