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H7250

Sigma-Aldrich

Histamine dihydrochloride

≥99% (TLC), powder, endogenous histamine receptor agonist

Synonym(s):

2-(4-Imidazolyl)ethylamine dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C5H9N3 · 2HCl
CAS Number:
56-92-8
Molecular Weight:
184.07
Beilstein/REAXYS Number:
3624116
EC Number:
200-298-4
MDL number:
MFCD00012703
UNSPSC Code:
12352116
eCl@ss:
32160406
PubChem Substance ID:
24277777
NACRES:
NA.77

product name

Histamine dihydrochloride, ≥99% (TLC), powder

Quality Level

200

assay

≥99% (TLC)

form

powder

color

white to off-white

mp

249-252 °C (lit.)

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].NCCc1c[nH]cn1

InChI

1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H

InChI key

PPZMYIBUHIPZOS-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269) , HRH2(3274)

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General description

Histamine dihydrochloride is a derivative of histamine. It prevents the formation of ROS (reactive oxygen species), which inhibits the activation of T cells and natural killer cells. Histamine dihydrochloride is implicated in tumor cell apoptosis. It prevents the relapse of acute myeloid leukemia in patients.

Application

Histamine dihydrochloride has been used:
  • as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP)
  • to determine its level in fish using HPLC (high performance liquid chromatography)
  • to assess the tracheal response to antigens in guinea-pigs

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nitric oxide as an orthograde cotransmitter at central synapses of Aplysia: responses of isolated neurons in culture
Jacklet JW and Koh HY
American Zoologist, 41(2), 282-291 (2001)
Maternal dietary antigens and the immune response in the offspring of the guinea-pig.
Telemo E, et al.
Immunology, 62(1), 35-35 (1987)
Histamine H4 receptor: a Novel Drug Target For Immunoregulation and Inflammation (2013)
Determination of some quality criteria of cold storaged marinated anchovy under vacuum and modified atmosphere conditions
Guncsen U, et al.
Turkish Journal of Fisheries and Aquatic Sciences, 11(2), 282-291 (2011)
Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid leukemia
Martner A, et al.
Expert Review of Hematology, 3(4), 381-391 (2010)
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