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H6501

Sigma-Aldrich

DL-β-Hydroxybutyric acid sodium salt

~98%, powder

Synonym(s):

(±)-3-Hydroxybutanoic acid sodium salt

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About This Item

Linear Formula:
C4H7O3Na
CAS Number:
150-83-4
Molecular Weight:
126.09
EC Number:
205-774-5
MDL number:
MFCD00016716
UNSPSC Code:
12352204
PubChem Substance ID:
24895744
NACRES:
NA.83

product name

DL-β-Hydroxybutyric acid sodium salt, ~98%

assay

~98%

Quality Level

200

form

powder

solubility

water: 1 g/10 mL, clear, colorless

storage temp.

2-8°C

SMILES string

[Na].CC(O)CC(O)=O

InChI

1S/C4H8O3.Na/c1-3(5)2-4(6)7;/h3,5H,2H2,1H3,(H,6,7);/q;+1/p-1

InChI key

NBPUSGBJDWCHKC-UHFFFAOYSA-M

Related Categories

Application

DL-β-Hydroxybutyric acid sodium salt has been used:
  • as a standard for quantifying blood plasma and milk β-hydroxybutyric acid in Danish Jersey cows
  • to investigate its anticonvulsant effects in epilepsy induced rats
  • to induce hyperketonemia in Holstein dairy cows

Biochem/physiol Actions

β-Hydroxybutyric acid is a ketone body present in the rumen epithelium of liver cells. Its interconversion to acetoacetate influences the acid-base balance and is coupled NADH generation from (nicotinamide adenine dinucleotide) NAD+, measured fluorimetrically. A high plasma level of β-hydroxybutyric acid is implicated in diabetic ketoacidosis. It traverses the blood-brain barrier as a monocarboxylic acid. β-Hydroxybutyric acid may play a protective role in dopaminergic neurodegeneration in Parkinson′s disease model. β-Hydroxybutyric acid is a ligand for G protein-coupled receptor(GPR109A) and favors inhibition of secretion, transcription and translation of growth hormone (GH) and prolactin (PRL) gene in cow anterior pituitary cells (DCAPCs).

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Influence of DL-beta-hydroxybutyric acid on cell proliferation and calcium influx
Cheng S, et al.
Biomacromolecules, 6(2), 593-597 (2005)
Fluorometric determination of beta-hydroxybutyrate in milk and blood plasma
Larsen T and Nielsen NI
Journal of Dairy Science, 88(6), 2004-2009 (2005)
Emily R Cope et al.
Physiological genomics, 50(6), 468-477 (2018-04-07)
To identify molecular pathways that couple metabolic imbalances and reproduction, we randomly assigned 10 castrated male sheep to be centrally injected into the lateral ventricle through intracerebroventricular cannulas with 1 ml of β-hydroxybutyric acid sodium salt solution (BHB; 12,800 µmol/l)
Jianping Si et al.
Experimental and therapeutic medicine, 14(1), 765-770 (2017-07-05)
The present study aimed to investigate the anticonvulsant effects of β-hydroxybutyrate (BHB) in a kainic acid (KA)-induced rat seizure model. The concentrations of BHB and glucose were detected in the blood prior to exogenous BHB administration. Three different doses of
M Lehmann et al.
Journal of dairy science, 96(2), 889-896 (2012-12-12)
During a mammary immune response, the integrity of the blood-milk barrier is negatively affected and becomes leaky. The aim of the present study was to demonstrate the blood origin, and to investigate changes in the concentration, of various constituents including
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