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C3042

Sigma-Aldrich

Corticotropin Releasing Factor human, rat

≥95% (HPLC), powder

Synonym(s):

CRF, CRH

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About This Item

Empirical Formula (Hill Notation):
C208H344N60O63S2
CAS Number:
86784-80-7
Molecular Weight:
4757.45
MDL number:
MFCD00213806
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human
rat

Quality Level

200

assay

≥95% (HPLC)

form

powder

mol wt

4757.45

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

activity assay: suitable

solubility

water: 1.00-1.04 mg/mL, colorless

UniProt accession no.

P06850

storage temp.

−20°C

InChI key

VXFVFWFSJFSXHN-FAUHKOHMSA-N

Gene Information

human ... CRH(1392)

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Amino Acid Sequence

Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2

General description

The corticotropin-releasing factor is a 41-amino-acid polypeptide. It is expressed in neurons, the hypothalamus, and the amygdala.

Research area: Neuroscience

Application

Corticotropin Releasing Factor human, rat has been used:
  • as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants
  • as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells
  • in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture
  • in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus

Biochem/physiol Actions

CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
Corticotropin-releasing factor modulates stress responses. It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders. Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.

Other Notes

Lyophilized from 0.1% TFA in H2O

antibody

Product No.
Description
Pricing

C5348

Anti-Corticotropin Releasing Factor antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

C0961

Corticotropin Releasing Factor Fragment 6-33 human, rat, ≥97% (HPLC)

C3042

Corticotropin Releasing Factor human, rat, ≥95% (HPLC), powder

A4933

Astressin, ≥90% (HPLC)

C2917

Corticotropin Releasing Factor Antagonist, ≥97% (HPLC)

C2671

Corticotropin Releasing Factor bovine, ≥90% (HPLC), Synthetic

WH0001392M2

Monoclonal Anti-CRH antibody produced in mouse, clone 2B11, purified immunoglobulin, buffered aqueous solution

GW22056

Anti-CRH antibody produced in chicken, affinity isolated antibody, buffered aqueous solution

SAB1405656

Anti-CRH antibody produced in mouse, purified immunoglobulin, buffered aqueous solution

APREST88883

PrEST Antigen CRH, Prestige Antigens™ Powered by Atlas Antibodies, buffered aqueous solution

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Anxiolytics.
Handbook of Clinical Neurophysiology, 106, 669-669 (2012)
Frameworks of alcohol addiction: alcohol addiction as a reward deficit and stress surfeit disorder
Frontiers in Psychiatry, 3-28 (2014)
Transcriptional regulation of hypothalamic corticotropin-releasing factor gene
Vitamins & Hormones, 82, 301-317 (2010)
Identification of brain target neurons using a fluorescent conjugate of corticotropin-releasing factor
Hubbard CS, et al.
Journal of Chemical Neuroanatomy, 37(4), 245-253 (2009)
Colette G Ngo Ndjom et al.
Frontiers in microbiology, 6, 279-279 (2015-04-24)
Streptococcus pneumoniae (S. pneumoniae), a commensal across the nasal passages, is responsible for the majority of infectious pneumonia cases worldwide. Previous studies have shown that hormonal factors may be influential in regulating S. pneumoniae's transition from a non-pathogen to a
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